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Gene Review:

Ptger3 - prostaglandin E receptor 3 (subtype EP3)

Rattus norvegicus

Synonyms: EP3, PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, Prostaglandin E2 receptor EP3 subtype, Prostanoid EP3 receptor, ...

Yamaguchi, T. et al., Zacharowski, K. et al., Kondo, K. et al.

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High impact information on Ptger3

In the present study, we investigated the participation of the prostanoid EP3 receptor, the target of PGE2 in the brain, in behavioral suppression induced by Delta8-tetrahydrocannabinol (Delta8-THC), an isomer of the naturally occurring Delta9-THC, using a one-lever operant task in rats [1].
Prostanoid EP3 receptor antisense-oligodeoxynucleotide (AS-ODN; twice a day for 3 days, i.c.v.) significantly decreased prostanoid EP3 receptor mRNA levels as determined by the RT-PCR analysis in the cerebral cortex, hippocampus and midbrain [1].
Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat [2].
1. This study investigates the effects of two agonists of the prostanoid EP3-receptor (M&B 28767 and GR 63799X) on the infarct size caused by regional myocardial ischaemia and reperfusion in the anaesthetized rat [2].
In contrast, the inhibitory effect of a prostanoid EP3-receptor agonist on PACAP-38-stimulated cyclic AMP formation was brain region-specific; the inhibitory action was observed in the cerebellum but not in the hippocampus [3].

References

Activation of brain prostanoid EP3 receptors via arachidonic acid cascade during behavioral suppression induced by Delta8-tetrahydrocannabinol. Yamaguchi, T., Kubota, T., Watanabe, S., Yamamoto, T. J. Neurochem. (2004) [Pubmed]
Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat. Zacharowski, K., Olbrich, A., Otto, M., Hafner, G., Thiemermann, C. Br. J. Pharmacol. (1999) [Pubmed]
Stimulation of cyclic AMP formation by pituitary adenylate cyclase-activating polypeptide is attenuated by glutamate in rat brain slices. Kondo, K., Hashimoto, H., Sakata, K., Saga, H., Kitanaka, J., Baba, A. Jpn. J. Pharmacol. (1995) [Pubmed]

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