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Gene Review

fdl  -  fused lobes

Drosophila melanogaster

Synonyms: CG8824, Dmel\CG8824, FDL, Fdl, Protein fused lobes, ...
 
 
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High impact information on fdl

  • Glycan profiles change during normal development consistent with increasing alpha-mannosidase II and core fucosyl-transferase enzyme activities, and with decreasing activity of the Fused lobes processing hexosaminidase [1].
  • Therefore, we conclude that the fdl gene encodes a novel hexosaminidase responsible for the occurrence of paucimannosidic N-glycans in Drosophila [2].
  • To determine whether the Drosophila melanogaster genome indeed encodes such an enzyme, a cDNA corresponding to fused lobes (fdl), a putative beta-N-acetylglucosaminidase with a potential transmembrane domain, was cloned [2].
  • The ratio of structures with terminal GlcNAc over those without (i.e. paucimannosidic N-glycans) was drastically increased in the fdl-deficient flies [2].
  • Although none of the genes was testis-specific, fdl was highly and preferentially expressed in the testis, whereas Hexo1 and Hexo2 showed broader tissue expression [3].
 

Analytical, diagnostic and therapeutic context of fdl

  • Finally, the N-glycans of two lines of fdl mutant flies were analyzed by mass spectrometry and reversed-phase high-performance liquid chromatography [2].

References

  1. Dynamic Developmental Elaboration of N-Linked Glycan Complexity in the Drosophila melanogaster Embryo. Aoki, K., Perlman, M., Lim, J.M., Cantu, R., Wells, L., Tiemeyer, M. J. Biol. Chem. (2007) [Pubmed]
  2. The Drosophila fused lobes gene encodes an N-acetylglucosaminidase involved in N-glycan processing. Léonard, R., Rendic, D., Rabouille, C., Wilson, I.B., Préat, T., Altmann, F. J. Biol. Chem. (2006) [Pubmed]
  3. Identification and expression analysis of Drosophila melanogaster genes encoding beta-hexosaminidases of the sperm plasma membrane. Cattaneo, F., Pasini, M.E., Intra, J., Matsumoto, M., Briani, F., Hoshi, M., Perotti, M.E. Glycobiology (2006) [Pubmed]
 
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