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Gene Review

alpha-Man-II  -  alpha Mannosidase II

Drosophila melanogaster

Synonyms: AMan II, Alpha-mannosidase 2, CG18474, CG18802, CG8139, ...
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Disease relevance of alpha-Man-II


High impact information on alpha-Man-II


Biological context of alpha-Man-II


Anatomical context of alpha-Man-II


Associations of alpha-Man-II with chemical compounds


Analytical, diagnostic and therapeutic context of alpha-Man-II


  1. Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. van den Elsen, J.M., Kuntz, D.A., Rose, D.R. EMBO J. (2001) [Pubmed]
  2. Dynamic Developmental Elaboration of N-Linked Glycan Complexity in the Drosophila melanogaster Embryo. Aoki, K., Perlman, M., Lim, J.M., Cantu, R., Wells, L., Tiemeyer, M. J. Biol. Chem. (2007) [Pubmed]
  3. Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. Numao, S., Kuntz, D.A., Withers, S.G., Rose, D.R. J. Biol. Chem. (2003) [Pubmed]
  4. Structural basis of the inhibition of golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions. Kawatkar, S.P., Kuntz, D.A., Woods, R.J., Rose, D.R., Boons, G.J. J. Am. Chem. Soc. (2006) [Pubmed]
  5. Cloning and sequence analysis of GmII, a Drosophila melanogaster homologue of the cDNA encoding murine Golgi alpha-mannosidase II. Foster, J.M., Yudkin, B., Lockyer, A.E., Roberts, D.B. Gene (1995) [Pubmed]
  6. Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Li, B., Kawatkar, S.P., George, S., Strachan, H., Woods, R.J., Siriwardena, A., Moremen, K.W., Boons, G.J. Chembiochem (2004) [Pubmed]
  7. The mammalian ARF-like protein 1 (Arl1) is associated with the Golgi complex. Lowe, S.L., Wong, S.H., Hong, W. J. Cell. Sci. (1996) [Pubmed]
  8. Comparison of kifunensine and 1-deoxymannojirimycin binding to class I and II alpha-mannosidases demonstrates different saccharide distortions in inverting and retaining catalytic mechanisms. Shah, N., Kuntz, D.A., Rose, D.R. Biochemistry (2003) [Pubmed]
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