Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Nr1d1 - nuclear receptor subfamily 1, group D,...

Rattus norvegicus

Synonyms: EAR-1, Nuclear receptor subfamily 1 group D member 1, Rev-erbA-alpha, V-erbA-related protein 1

Lazar, M.A. et al., Spanjaard, R.A. et al., Harding, H.P. et al., Bradley, D.J. et al.

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High impact information on Nr1d1

REV-ErbA alpha mRNA was highest in the neocortex [1].
The orphan receptor Rev-ErbA alpha activates transcription via a novel response element [2].
A cDNA encoding a novel member of the thyroid/steroid hormone receptor superfamily, called Rev-ErbA alpha, has been isolated from a rat GH3 cell library [3].
Rev-ErbA alpha is an approximately 56-kilodalton protein most similar in structure to the thyroid hormone receptor (c-erbA) and the retinoic acid receptor, but it does not bind either thyroid hormone or retinoic acid [3].
The mRNA encoding Rev-ErbA alpha is present in many tissues and is particularly abundant in skeletal muscle and brown fat [3].

Other interactions of Nr1d1

Rat Rev-erbA alpha, an orphan receptor related to thyroid hormone receptor, binds to specific thyroid hormone response elements [4].

References

Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary. Bradley, D.J., Young, W.S., Weinberger, C. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
The orphan receptor Rev-ErbA alpha activates transcription via a novel response element. Harding, H.P., Lazar, M.A. Mol. Cell. Biol. (1993) [Pubmed]
A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Lazar, M.A., Hodin, R.A., Darling, D.S., Chin, W.W. Mol. Cell. Biol. (1989) [Pubmed]
Rat Rev-erbA alpha, an orphan receptor related to thyroid hormone receptor, binds to specific thyroid hormone response elements. Spanjaard, R.A., Nguyen, V.P., Chin, W.W. Mol. Endocrinol. (1994) [Pubmed]

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