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Gene Review

Nr1d1  -  nuclear receptor subfamily 1, group D,...

Mus musculus

Synonyms: A530070C09Rik, EAR-1, Ear1, Nuclear receptor subfamily 1 group D member 1, R75201, ...
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High impact information on Nr1d1


Biological context of Nr1d1


Anatomical context of Nr1d1

  • The role of the orphan nuclear receptor Rev-Erb alpha in adipocyte differentiation and function [5].
  • Rev-erb alpha is highly expressed in adipose tissue, skeletal muscle, heart, liver and brain [5].
  • The expression of clock-control genes, such as Bmal1 and Rev-erbalpha, also displays diurnal oscillations in the uterus, but not in bone [8].
  • In experiments with cultured cells, we show here that GSK3beta phosphorylates and stabilizes the orphan nuclear receptor Rev-erbalpha, a negative component of the circadian clock [9].
  • In the present study, transient cotransfection experiments in rat hepatocytes in primary culture and rabbit kidney RK13 cells demonstrated that overexpression of Rev-erbalpha specifically decreases basal and HNF-4 stimulated human apoC-III promoter activity [10].

Associations of Nr1d1 with chemical compounds

  • The DNA binding domains of Rev-erb alpha and beta are highly related to each other and to the retinoic acid related orphan receptor (ROR)/RZR subfamily of nuclear receptors [4].
  • Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock [9].

Other interactions of Nr1d1

  • On the other hand, the expression levels of DBP and Rev-erbalpha mRNAs were blunted in Clock mutant mice not only under ad libitum but also under RF conditions [11].
  • Meal timing reversed the chronic jet lag-induced alterations in Rev-erbalpha and Per2 expression in liver and of all three clock genes in tumor and slowed tumor growth [12].

Analytical, diagnostic and therapeutic context of Nr1d1


  1. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Preitner, N., Damiola, F., Lopez-Molina, L., Zakany, J., Duboule, D., Albrecht, U., Schibler, U. Cell (2002) [Pubmed]
  2. Twenty-four-hour rhythmic gene expression in the rhesus macaque adrenal gland. Lemos, D.R., Downs, J.L., Urbanski, H.F. Mol. Endocrinol. (2006) [Pubmed]
  3. The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Yin, L., Lazar, M.A. Mol. Endocrinol. (2005) [Pubmed]
  4. Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Forman, B.M., Chen, J., Blumberg, B., Kliewer, S.A., Henshaw, R., Ong, E.S., Evans, R.M. Mol. Endocrinol. (1994) [Pubmed]
  5. The role of the orphan nuclear receptor Rev-Erb alpha in adipocyte differentiation and function. Laitinen, S., Fontaine, C., Fruchart, J.C., Staels, B. Biochimie (2005) [Pubmed]
  6. Mapping of binding regions for the circadian regulators BMAL1 and CLOCK within the mouse Rev-erbalpha gene. Ripperger, J.A. Chronobiol. Int. (2006) [Pubmed]
  7. Modeling feedback loops of the Mammalian circadian oscillator. Becker-Weimann, S., Wolf, J., Herzel, H., Kramer, A. Biophys. J. (2004) [Pubmed]
  8. Expression of the orphan nuclear receptor ERRalpha is under circadian regulation in estrogen-responsive tissues. Horard, B., Rayet, B., Triqueneaux, G., Laudet, V., Delaunay, F., Vanacker, J.M. J. Mol. Endocrinol. (2004) [Pubmed]
  9. Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Yin, L., Wang, J., Klein, P.S., Lazar, M.A. Science (2006) [Pubmed]
  10. Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription. Raspé, E., Duez, H., Mansén, A., Fontaine, C., Fiévet, C., Fruchart, J.C., Vennström, B., Staels, B. J. Lipid Res. (2002) [Pubmed]
  11. Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding: entrainable expression of mPer2 and BMAL1 mRNAs in the heart of Clock mutant mice on Jcl:ICR background. Oishi, K., Miyazaki, K., Ishida, N. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  12. Effects of light and food schedules on liver and tumor molecular clocks in mice. Filipski, E., Innominato, P.F., Wu, M., Li, X.M., Iacobelli, S., Xian, L.J., Lévi, F. J. Natl. Cancer Inst. (2005) [Pubmed]
  13. Rev-erbalpha gene expression in the mouse brain with special emphasis on its circadian profiles in the suprachiasmatic nucleus. Onishi, H., Yamaguchi, S., Yagita, K., Ishida, Y., Dong, X., Kimura, H., Jing, Z., Ohara, H., Okamura, H. J. Neurosci. Res. (2002) [Pubmed]
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