The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

cfr  -  florfenicol/chloramphenicol resistance...

Staphylococcus sciuri

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cfr


High impact information on cfr

  • During a study of florfenicol-resistant porcine staphylococci from Denmark, the genes cfr and fexA were detected in the chromosomal DNA or on plasmids of Staphylococcus hyicus, Staphylococcus warneri, and Staphylococcus simulans [3].
  • This resistance gene region consisted of the clindamycin exporter gene lsa(B) and the gene cfr for combined resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics bracketed by IS21-558 insertion sequences orientated in the same direction [3].
  • A total of 302 chloramphenicol-resistant Staphylococcus isolates were screened for the presence of the florfenicol/chloramphenicol resistance genes fexA and cfr and their localization on mobile genetic elements [2].
  • The cfr gene has previously been identified as a phenicol and lincosamide resistance gene on plasmids isolated from Staphylococcus spp. of animal origin and recently shown to encode a methyltransferase that modifies 23S rRNA at A2503 [4].

Biological context of cfr

  • Truncated copies of Tn558, in which the tnpA-tnpB area was in part deleted by the integration of a 4,674-bp segment including the gene cfr and a novel 2,446-bp IS21-like insertion sequence, were seen in a plasmid present in three staphylococcal isolates [2].

Associations of cfr with chemical compounds

  • In addition to the previously described genes cfr for chloramphenicol/florfenicol resistance and erm(33) for inducible resistance to macrolide-lincosamide-streptogramin B resistance, a Tn554-like spectinomycin resistance gene and Tn554-related transposase genes were identified [5].

Analytical, diagnostic and therapeutic context of cfr

  • Transpositionally active forms of the IS21-558 element, known as minicircles, were detected by PCR and suggest that this insertion sequence is involved in the mobility of the multiresistance gene cfr [3].


  1. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Kehrenberg, C., Schwarz, S., Jacobsen, L., Hansen, L.H., Vester, B. Mol. Microbiol. (2005) [Pubmed]
  2. Distribution of Florfenicol Resistance Genes fexA and cfr among Chloramphenicol-Resistant Staphylococcus Isolates. Kehrenberg, C., Schwarz, S. Antimicrob. Agents Chemother. (2006) [Pubmed]
  3. IS21-558 Insertion Sequences Are Involved in the Mobility of the Multiresistance Gene cfr. Kehrenberg, C., Aarestrup, F.M., Schwarz, S. Antimicrob. Agents Chemother. (2007) [Pubmed]
  4. The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. Long, K.S., Poehlsgaard, J., Kehrenberg, C., Schwarz, S., Vester, B. Antimicrob. Agents Chemother. (2006) [Pubmed]
  5. Nucleotide sequence and organization of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri. Kehrenberg, C., Ojo, K.K., Schwarz, S. J. Antimicrob. Chemother. (2004) [Pubmed]
WikiGenes - Universities