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Gene Review:

cds1 - replication checkpoint kinase cds1

Schizosaccharomyces pombe 972h-

Sugimoto, I. et al., Borgne, A. et al., Nilssen, E.A. et al., Fung, A.D. et al., Brondello, J.M. et al., et al.

Borgne, Nurse,

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High impact information on cds1

Irradiated cells eventually progress into S phase and arrest in early S by a rad3- and cds1-dependent mechanism, most likely the intra-S checkpoint [1].
The motif C mutants are most sensitive to MMS during S phase and are partially suppressed by deletion of the S-phase checkpoint kinase cds1 [2].
Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity [3].
IR activates Cds1 only during the DNA synthesis (S) phase, whereas HU induces Chk1 phosphorylation only in cds1 mutants [4].
In the presence of the DNA replication inhibitor hydroxyurea (HU), cds1 mad2 cells entered and progressed through mitosis earlier than did cds1 cells [5].

Biological context of cds1

In contrast, the entry of cds1 mutant cells into mitosis is delayed by several hours when DNA replication is inhibited [5].

Other interactions of cds1

High levels of Spd1p lead to an increase in Y15 phosphorylation of Cdc2p and we show that the block over G(2) requires the Wee1p kinase and is dependent on the rad and chk1/cds1 checkpoint genes [6].

References

Intra-G1 arrest in response to UV irradiation in fission yeast. Nilssen, E.A., Synnes, M., Kleckner, N., Grallert, B., Boye, E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase. Fung, A.D., Ou, J., Bueler, S., Brown, G.W. Mol. Cell. Biol. (2002) [Pubmed]
Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity. Snaith, H.A., Brown, G.W., Forsburg, S.L. Mol. Cell. Biol. (2000) [Pubmed]
Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases. Brondello, J.M., Boddy, M.N., Furnari, B., Russell, P. Mol. Cell. Biol. (1999) [Pubmed]
DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast. Sugimoto, I., Murakami, H., Tonami, Y., Moriyama, A., Nakanishi, M. J. Biol. Chem. (2004) [Pubmed]
The Spd1p S phase inhibitor can activate the DNA replication checkpoint pathway in fission yeast. Borgne, A., Nurse, P. J. Cell. Sci. (2000) [Pubmed]

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MGG_04790	Magnaporthe oryzae 70-15
NCU02751	Neurospora crassa OR74A

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