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Gene Review

cds1  -  replication checkpoint kinase cds1

Schizosaccharomyces pombe 972h-

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High impact information on cds1


Biological context of cds1


Other interactions of cds1

  • High levels of Spd1p lead to an increase in Y15 phosphorylation of Cdc2p and we show that the block over G(2) requires the Wee1p kinase and is dependent on the rad and chk1/cds1 checkpoint genes [6].


  1. Intra-G1 arrest in response to UV irradiation in fission yeast. Nilssen, E.A., Synnes, M., Kleckner, N., Grallert, B., Boye, E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase. Fung, A.D., Ou, J., Bueler, S., Brown, G.W. Mol. Cell. Biol. (2002) [Pubmed]
  3. Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity. Snaith, H.A., Brown, G.W., Forsburg, S.L. Mol. Cell. Biol. (2000) [Pubmed]
  4. Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases. Brondello, J.M., Boddy, M.N., Furnari, B., Russell, P. Mol. Cell. Biol. (1999) [Pubmed]
  5. DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast. Sugimoto, I., Murakami, H., Tonami, Y., Moriyama, A., Nakanishi, M. J. Biol. Chem. (2004) [Pubmed]
  6. The Spd1p S phase inhibitor can activate the DNA replication checkpoint pathway in fission yeast. Borgne, A., Nurse, P. J. Cell. Sci. (2000) [Pubmed]
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