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Gene Review:

rik1 - silencing protein Rik1

Schizosaccharomyces pombe 972h-

Appelgren, H. et al., Li, F. et al., Ekwall, K. et al., Allshire, R.C. et al.

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High impact information on rik1

Strains with lesions at the clr4, rik1, and swi6 loci have highly elevated rates of chromosome loss [1].
Two novel proteins, dos1 and dos2, interact with rik1 to regulate heterochromatic RNA interference and histone modification [2].
Time-lapse microscopy of live mis6 and nuf2-1 mutant cells in mitosis showed similar severe misaggregation phenotypes whereas the rik1 mutants showed a mild cohesion defect [3].
Transacting mutations affecting the kinetochore (nuf2) central core domain (mis6) and the heterochromatin domain (rik1) were analyzed in live cells [3].

Biological context of rik1

Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast [4].

References

Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Allshire, R.C., Nimmo, E.R., Ekwall, K., Javerzat, J.P., Cranston, G. Genes Dev. (1995) [Pubmed]
Two novel proteins, dos1 and dos2, interact with rik1 to regulate heterochromatic RNA interference and histone modification. Li, F., Goto, D.B., Zaratiegui, M., Tang, X., Martienssen, R., Cande, W.Z. Curr. Biol. (2005) [Pubmed]
Distinct centromere domain structures with separate functions demonstrated in live fission yeast cells. Appelgren, H., Kniola, B., Ekwall, K. J. Cell. Sci. (2003) [Pubmed]
Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Ekwall, K., Ruusala, T. Genetics (1994) [Pubmed]

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