Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

clr4 - histone H3 methyltransferase Clr4

Schizosaccharomyces pombe 972h-

Ivanova, A.V. et al., Doe, C.L. et al., Ekwall, K. et al., Allshire, R.C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on clr4

These results show that clr4 plays a critical role in silencing at mating-type loci and centromeres through the organization of repressive chromatin structure and demonstrate a new, activator function for Clr4p [1].
Surprisingly, RNA differential display experiments demonstrated that clr4+ can mediate transcriptional activation of certain other loci [1].
Strains with lesions at the clr4, rik1, and swi6 loci have highly elevated rates of chromosome loss [2].
In the absence of Chp1p protein, cells are viable but show chromosome segregation defects such as lagging chromosomes on the spindle during anaphase and high rates of minichromosome loss, phenotypes which are also displayed by swi 6 and clr 4 [3].
The mutations define three new genes, clr2, clr3 and clr4 [4].

Biological context of clr4

Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast [4].

References

The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast. Ivanova, A.V., Bonaduce, M.J., Ivanov, S.V., Klar, A.J. Nat. Genet. (1998) [Pubmed]
Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Allshire, R.C., Nimmo, E.R., Ekwall, K., Javerzat, J.P., Cranston, G. Genes Dev. (1995) [Pubmed]
The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin. Doe, C.L., Wang, G., Chow, C., Fricker, M.D., Singh, P.B., Mellor, E.J. Nucleic Acids Res. (1998) [Pubmed]
Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Ekwall, K., Ruusala, T. Genetics (1994) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg