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Gene Review

clr4  -  histone H3 methyltransferase Clr4

Schizosaccharomyces pombe 972h-

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High impact information on clr4


Biological context of clr4


  1. The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast. Ivanova, A.V., Bonaduce, M.J., Ivanov, S.V., Klar, A.J. Nat. Genet. (1998) [Pubmed]
  2. Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Allshire, R.C., Nimmo, E.R., Ekwall, K., Javerzat, J.P., Cranston, G. Genes Dev. (1995) [Pubmed]
  3. The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin. Doe, C.L., Wang, G., Chow, C., Fricker, M.D., Singh, P.B., Mellor, E.J. Nucleic Acids Res. (1998) [Pubmed]
  4. Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Ekwall, K., Ruusala, T. Genetics (1994) [Pubmed]
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