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Gene Review:

aph1 - bis(5'-nucleosidyl)-tetraphosphatase

Schizosaccharomyces pombe 972h-

Huang, Y. et al., Ingram, S.W. et al.

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High impact information on aph1

We describe a new S. pombe expression plasmid, pPOX, which was used to achieve the largest increase in expression of aph1 [1].
The intron boundaries were confirmed by sequencing the cDNA of the aph1 gene from a S. pombe cDNA library [2].
The deduced open reading frame of the aph1 gene codes for 182 amino acids [2].
The aph1 gene from S. pombe contains three introns [2].

Analytical, diagnostic and therapeutic context of aph1

The 60 bp DNA fragment obtained by PCR, which is specific to Ap4A hydrolase, was used to isolate the Ap4A hydrolase gene, aph1, from S. pombe by screening a genomic DNA library in a multicopy plasmid [2].

References

Disruption and overexpression of the Schizosaccharomyces pombe aph1 gene and the effects on intracellular diadenosine 5',5'''-P1, P4-tetraphosphate (Ap4A), ATP and ADP concentrations. Ingram, S.W., Barnes, L.D. Biochem. J. (2000) [Pubmed]
Cloning of the Schizosaccharomyces pombe gene encoding diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) asymmetrical hydrolase: sequence similarity with the histidine triad (HIT) protein family. Huang, Y., Garrison, P.N., Barnes, L.D. Biochem. J. (1995) [Pubmed]

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