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Gene Review

Fhit  -  fragile histidine triad

Rattus norvegicus

Synonyms: AP3A hydrolase, AP3Aase, Bis(5'-adenosyl)-triphosphatase, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, Dinucleosidetriphosphatase, ...
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Disease relevance of Fhit


High impact information on Fhit

  • Thus, in carcinogen-exposed rat tissues there is an overall association of Fhit expression with regulatory region methylation, and hypermethylation patterns did not vary with carcinogen [3].
  • Treatment of rat cancer cells in vitro with the DNA methyltransferase inhibitor, 5'-Aza-2'deoxycytidine, for 4 d, increased Fhit expression and altered the methylation status [3].
  • We previously observed decreased Fhit expression and Fhit promoter region hypermethylation in rodent tumors induced by various carcinogens, and noted that the 5' regulatory regions in the promoter, exon 1, and intron 1 were differentially methylated, depending on the tissue of origin [3].
  • Fhit gene alterations in hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet in rats [4].

Biological context of Fhit


Analytical, diagnostic and therapeutic context of Fhit


  1. FHIT alterations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Murata, N., Tsutsumi, M., Konishi, Y., Nakae, D. Carcinogenesis (2001) [Pubmed]
  2. Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. Tsujiuchi, T., Sasaki, Y., Kubozoe, T., Tsutsumi, M., Konishi, Y., Nakae, D. Mol. Carcinog. (2002) [Pubmed]
  3. Hypermethylation patterns in the Fhit regulatory region are tissue specific. Guler, G., Iliopoulos, D., Han, S.Y., Fong, L.Y., Lubet, R.A., Grubbs, C.J., Huebner, K. Mol. Carcinog. (2005) [Pubmed]
  4. Fhit gene alterations in hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet in rats. Tsujiuchi, T., Sasaki, Y., Oka, Y., Konishi, Y., Tsutsumi, M. Mol. Carcinog. (2003) [Pubmed]
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