Gene Review:
Fhit - fragile histidine triad gene
Mus musculus
Synonyms:
AP3A hydrolase, AP3Aase, AW045638, Bis(5'-adenosyl)-triphosphatase, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, ...
- The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells. Pekarsky, Y., Druck, T., Cotticelli, M.G., Ohta, M., Shou, J., Mendrola, J., Montgomery, J.C., Buchberg, A.M., Siracusa, L.D., Manenti, G., Fong, L.Y., Dragani, T.A., Croce, C.M., Huebner, K. Cancer Res. (1998)
- Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit. Shiraishi, T., Druck, T., Mimori, K., Flomenberg, J., Berk, L., Alder, H., Miller, W., Huebner, K., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. Zanesi, N., Mancini, R., Sevignani, C., Vecchione, A., Kaou, M., Valtieri, M., Calin, G.A., Pekarsky, Y., Gnarra, J.R., Croce, C.M., Huebner, K. Cancer Res. (2005)
- Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells. Wu, R., Connolly, D.C., Dunn, R.L., Cho, K.R. J. Natl. Cancer Inst. (2000)
- Novel tumor suppressor locus in human chromosome region 3p14.2. Jülicher, K., Marquitan, G., Werner, N., Bardenheuer, W., Vieten, L., Bröcker, F., Topal, H., Seeber, S., Opalka, B., Schütte, J. J. Natl. Cancer Inst. (1999)
- Fhit is a physiological target of the protein kinase Src. Pekarsky, Y., Garrison, P.N., Palamarchuk, A., Zanesi, N., Aqeilan, R.I., Huebner, K., Barnes, L.D., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding. Trapasso, F., Krakowiak, A., Cesari, R., Arkles, J., Yendamuri, S., Ishii, H., Vecchione, A., Kuroki, T., Bieganowski, P., Pace, H.C., Huebner, K., Croce, C.M., Brenner, C. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression. Semba, S., Huebner, K. Mol. Cancer Res. (2006)
- Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas. Kowara, R., Salnikow, K., Diwan, B.A., Bare, R.M., Waalkes, M.P., Kasprzak, K.S. Mol. Cell. Biochem. (2004)
- Fhit and CHK1 have opposing effects on homologous recombination repair. Hu, B., Wang, H., Wang, X., Lu, H.R., Huang, C., Powell, S.N., Huebner, K., Wang, Y. Cancer Res. (2005)
- A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy and cancer prevention. Zanesi, N., Pekarsky, Y., Croce, C.M. Mutat. Res. (2005)
- Muir-Torre-like syndrome in Fhit-deficient mice. Fong, L.Y., Fidanza, V., Zanesi, N., Lock, L.F., Siracusa, L.D., Mancini, R., Siprashvili, Z., Ottey, M., Martin, S.E., Druck, T., McCue, P.A., Croce, C.M., Huebner, K. Proc. Natl. Acad. Sci. U.S.A. (2000)
- The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region. Glover, T.W., Hoge, A.W., Miller, D.E., Ascara-Wilke, J.E., Adam, A.N., Dagenais, S.L., Wilke, C.M., Dierick, H.A., Beer, D.G. Cancer Res. (1998)
- Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice. Fujishita, T., Doi, Y., Sonoshita, M., Hiai, H., Oshima, M., Huebner, K., Croce, C.M., Taketo, M.M. Br. J. Cancer (2004)
- Absence or reduction of Fhit expression in most clear cell renal carcinomas. Hadaczek, P., Siprashvili, Z., Markiewski, M., Domagala, W., Druck, T., McCue, P.A., Pekarsky, Y., Ohta, M., Huebner, K., Lubinski, J. Cancer Res. (1998)
- Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Pekarsky, Y., Campiglio, M., Siprashvili, Z., Druck, T., Sedkov, Y., Tillib, S., Draganescu, A., Wermuth, P., Rothman, J.H., Huebner, K., Buchberg, A.M., Mazo, A., Brenner, C., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- The tumor spectrum in FHIT-deficient mice. Zanesi, N., Fidanza, V., Fong, L.Y., Mancini, R., Druck, T., Valtieri, M., Rüdiger, T., McCue, P.A., Croce, C.M., Huebner, K. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Inactivation of the FHIT gene favors bladder cancer development. Vecchione, A., Sevignani, C., Giarnieri, E., Zanesi, N., Ishii, H., Cesari, R., Fong, L.Y., Gomella, L.G., Croce, C.M., Baffa, R. Clin. Cancer Res. (2004)
- Replacement of Fhit in cancer cells suppresses tumorigenicity. Siprashvili, Z., Sozzi, G., Barnes, L.D., McCue, P., Robinson, A.K., Eryomin, V., Sard, L., Tagliabue, E., Greco, A., Fusetti, L., Schwartz, G., Pierotti, M.A., Croce, C.M., Huebner, K. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. Pace, H.C., Hodawadekar, S.C., Draganescu, A., Huang, J., Bieganowski, P., Pekarsky, Y., Croce, C.M., Brenner, C. Curr. Biol. (2000)
- Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells. Ishii, H., Dumon, K.R., Vecchione, A., Trapasso, F., Mimori, K., Alder, H., Mori, M., Sozzi, G., Baffa, R., Huebner, K., Croce, C.M. Cancer Res. (2001)
- FHIT gene therapy prevents tumor development in Fhit-deficient mice. Dumon, K.R., Ishii, H., Fong, L.Y., Zanesi, N., Fidanza, V., Mancini, R., Vecchione, A., Baffa, R., Trapasso, F., During, M.J., Huebner, K., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. Han, S.Y., Iliopoulos, D., Druck, T., Guler, G., Grubbs, C.J., Pereira, M., Zhang, Z., You, M., Lubet, R.A., Fong, L.Y., Huebner, K. Oncogene (2004)