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Gene Review:

ptc1 - protein phosphatase 2C Ptc1

Schizosaccharomyces pombe 972h-

Shiozaki, K. et al., Shiozaki, K. et al.

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High impact information on ptc1

Genetic suppression of delta ptc1 delta ptc3 lethality identified two loci, mutations of which render cells hypersensitive to high-osmolarity media [1].
Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe [2].
We discovered ptc1+ (phosphatase two C) as a multicopy suppressor gene of swo1-26, a temperature-sensitive mutation of a gene encoding the heat shock protein hsp90 [2].
A ptc1 deletion mutant is viable and has approximately normal levels of PP2C activity, observations consistent with the fact that ptc1+ is a member of a multigene family [2].

References

Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast. Shiozaki, K., Russell, P. EMBO J. (1995) [Pubmed]
Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe. Shiozaki, K., Akhavan-Niaki, H., McGowan, C.H., Russell, P. Mol. Cell. Biol. (1994) [Pubmed]

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AGOS_AEL010W	Ashbya gossypii ATCC 10895
KLLA0F14729g	Kluyveromyces lactis NRRL Y-1140
MGG_05207	Magnaporthe oryzae 70-15
NCU00434	Neurospora crassa OR74A
Os04g0659500	Oryza sativa Japonica Group
PTC1	Saccharomyces cerevisiae S288c

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