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Gene Review

top3  -  DNA topoisomerase III

Schizosaccharomyces pombe 972h-

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High impact information on top3


Biological context of top3

  • Despite activation of this checkpoint, top3 cells exit the arrest but fail to undergo faithful chromosome segregation [1].
  • Fission yeast haploid spores containing a disrupted top3 (+)gene germinate successfully, but then undergo only a limited number of cell divisions [3].


  1. Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity. Win, T.Z., Goodwin, A., Hickson, I.D., Norbury, C.J., Wang, S.W. J. Cell. Sci. (2004) [Pubmed]
  2. Topoisomerase III is required for accurate DNA replication and chromosome segregation in Schizosaccharomyces pombe. Oh, M., Choi, I.S., Park, S.D. Nucleic Acids Res. (2002) [Pubmed]
  3. Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe. Goodwin, A., Wang, S.W., Toda, T., Norbury, C., Hickson, I.D. Nucleic Acids Res. (1999) [Pubmed]
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