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Gene Review

SWI6  -  Swi6p

Saccharomyces cerevisiae S288c

Synonyms: Cell-cycle box factor subunit SWI6, L9470.8, MBF subunit P90, PSL8, Regulatory protein SWI6, ...
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Disease relevance of SWI6


High impact information on SWI6

  • The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast [2].
  • SWI4 and SWI6 are transcription factors required for the START-dependent activation of the HO endonuclease gene [2].
  • The related Swi4 and Mbp1 proteins are the DNA-binding components of the respective factors, and Swi6 mayhave a regulatory function [3].
  • A related factor (MBF) containing SWI6 and a 120K protein binds to the ACGCGTNA (MCB) promoter elements responsible for late G1-specific transcription of DNA replication genes [4].
  • A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast [5].

Biological context of SWI6


Anatomical context of SWI6

  • Taken together, these data indicate that the transcription factor Swi6p and the Rpd3p-based deacetylase complex act in parallel pathways to activate genes required for cell wall biosynthesis [10].

Associations of SWI6 with chemical compounds

  • Moreover, because overexpression of NHP6A can suppress caffeine sensitivity of one of the SWI6 ANK mutants, swi6-405, other SWI6-dependent genes may also be affected by Nhp6A [8].
  • We find that swi4, swi6, and hrr25 mutants, but not mbp1 mutants, are sensitive to hydroxyurea and the DNA-damaging agent methyl methane-sulfonate and are defective in the transcriptional induction of a subset of DNA damage-inducible genes [11].
  • Both the sensitivity of swi6 mutants to methyl methanesulfonate and hydroxyurea and the transcriptional defect of hrr25 mutants are rescued by overexpression of SWI4, implicating the SBF complex in the Hrr25/Swi6-dependent response to DNA damage [11].
  • Alanine substitutions in both TPLH repeats of SWI6 reduce its activity but do not affect the stability of the protein or its association with SWI4 [12].
  • Nuclear import of Swi6 occurs concomitantly with dephosphorylation of serine 160 in late M phase [13].

Physical interactions of SWI6

  • We show here that SWI4 contains a novel DNA-binding domain at its N terminus that alone binds specifically to SCBs and a C-terminal domain that binds to SWI6 [4].
  • G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1 [14].

Enzymatic interactions of SWI6


Regulatory relationships of SWI6


Other interactions of SWI6

  • CLN3 function is, however, also dependent on SWI4 and SWI6 [2].
  • The HO promoter contains 10 copies of a cell cycle-regulated upstream activation sequence, which is activated by SWI4 and SWI6 [18].
  • On the basis of these observations, we suggest that the Rad53-dependent phosphorylation of Swi6 may delay the transition to S phase by inhibiting CLN transcription [19].
  • The Swi6 protein interacts with Swi4 to form the SBF complex and with Mbp1 to form the MBF complex [11].
  • The transcript levels of the recombination genes RAD51 and RAD54 , which have MCB elements, were reduced in Delta swi6 cells [7].

Analytical, diagnostic and therapeutic context of SWI6

  • Site-directed mutagenesis, based on a modeled three-dimensional structure of the swi6p chromodomain, shows that the hydrophobic amino acids which lie in the core of the structure are critical for biological function [20].


  1. Regulation of cell cycle transcription factor Swi4 through auto-inhibition of DNA binding. Baetz, K., Andrews, B. Mol. Cell. Biol. (1999) [Pubmed]
  2. The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Nasmyth, K., Dirick, L. Cell (1991) [Pubmed]
  3. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Iyer, V.R., Horak, C.E., Scafe, C.S., Botstein, D., Snyder, M., Brown, P.O. Nature (2001) [Pubmed]
  4. Anatomy of a transcription factor important for the start of the cell cycle in Saccharomyces cerevisiae. Primig, M., Sockanathan, S., Auer, H., Nasmyth, K. Nature (1992) [Pubmed]
  5. A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast. Dirick, L., Moll, T., Auer, H., Nasmyth, K. Nature (1992) [Pubmed]
  6. Regulation of the yeast DNA replication genes through the Mlu I cell cycle box is dependent on SWI6. Verma, R., Smiley, J., Andrews, B., Campbell, J.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  7. Meiotic role of SWI6 in Saccharomyces cerevisiae. Leem, S.H., Chung, C.N., Sunwoo, Y., Araki, H. Nucleic Acids Res. (1998) [Pubmed]
  8. The MSN1 and NHP6A genes suppress SWI6 defects in Saccharomyces cerevisiae. Sidorova, J., Breeden, L. Genetics (1999) [Pubmed]
  9. A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription. Macpherson, N., Measday, V., Moore, L., Andrews, B. Genetics (2000) [Pubmed]
  10. A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae. Vannier, D., Damay, P., Shore, D. Mol. Genet. Genomics (2001) [Pubmed]
  11. Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae. Ho, Y., Mason, S., Kobayashi, R., Hoekstra, M., Andrews, B. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  12. Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae. Sidorova, J., Breeden, L. Mol. Cell. Biol. (1993) [Pubmed]
  13. Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6. Geymonat, M., Spanos, A., Wells, G.P., Smerdon, S.J., Sedgwick, S.G. Mol. Cell. Biol. (2004) [Pubmed]
  14. G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1. Costanzo, M., Schub, O., Andrews, B. Mol. Cell. Biol. (2003) [Pubmed]
  15. Multiple SWI6-dependent cis-acting elements control SWI4 transcription through the cell cycle. Foster, R., Mikesell, G.E., Breeden, L. Mol. Cell. Biol. (1993) [Pubmed]
  16. The G(1) cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6. Wijnen, H., Landman, A., Futcher, B. Mol. Cell. Biol. (2002) [Pubmed]
  17. Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling. Queralt, E., Igual, J.C. Mol. Cell. Biol. (2003) [Pubmed]
  18. Cell cycle-specific expression of the SWI4 transcription factor is required for the cell cycle regulation of HO transcription. Breeden, L., Mikesell, G.E. Genes Dev. (1991) [Pubmed]
  19. Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Sidorova, J.M., Breeden, L.L. Genes Dev. (1997) [Pubmed]
  20. Conservation of heterochromatin protein 1 function. Wang, G., Ma, A., Chow, C.M., Horsley, D., Brown, N.R., Cowell, I.G., Singh, P.B. Mol. Cell. Biol. (2000) [Pubmed]
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