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Gene Review

CDC10  -  septin CDC10

Saccharomyces cerevisiae S288c

Synonyms: Cell division control protein 10, YCR002C, YCR022, YCR2C
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High impact information on CDC10

  • The SWI6 protein is similar to the protein in Schizosaccharomyces pombe that is encoded by cdc10 an essential gene specifically required at the start of the cell cycle [1].
  • The centromeric DNA (CEN3) from yeast chromosome III has been isolated on a 1.6 kilobase-pair segment of DNA located near the centromere-linked CDC10 locus of Saccharomyces cerevisiae [2].
  • Our results indicate that there are two cdc10-containing heteromeric complexes that bind to MCB elements and play differential roles in mitotic division and meiosis [3].
  • We show that Cdc10 and Cdc12 possess GTPase activity and appropriate mutations in conserved nucleotide-binding residues abrogate GTP binding and/or hydrolysis in vitro [4].
  • CDC10 is a gene encoding a neck filament-associated protein that is necessary for polarized growth and cytokinesis [5].

Biological context of CDC10


Associations of CDC10 with chemical compounds

  • Furthermore, transcripts from GAL10 and CDC10 genes, which are believed to be dispensable for sporulation, were much more abundant in sporulating cells than in asporogenous cells and vegetative cells grown on glucose or acetate [11].

Physical interactions of CDC10

  • CDC10 encodes a conserved potential GTP-binding protein that previously has been shown to localize to the bud neck and to be important for cytokinesis [12].

Other interactions of CDC10

  • In addition, the cdc10 mutant did not prevent actin localization at the budding site [7].
  • We have isolated and characterized C. albicans homologs of the S. cerevisiae CDC3 and CDC10 genes [13].
  • In this report, a genetic screen was used to isolate a novel ochre allele of CDC10, cdc10-10; strains containing this mutation require the SPA2 gene for growth [12].
  • In the leu2-cdc10 interval, the relationship between physical distance on the DNA and genetic distance as measured by recombinational frequencies is about 3 kilobase pairs per centimorgan [6].

Analytical, diagnostic and therapeutic context of CDC10


  1. Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila. Breeden, L., Nasmyth, K. Nature (1987) [Pubmed]
  2. Isolation of a yeast centromere and construction of functional small circular chromosomes. Clarke, L., Carbon, J. Nature (1980) [Pubmed]
  3. pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for meiosis in the fission yeast Schizosaccharomyces pombe. Zhu, Y., Takeda, T., Nasmyth, K., Jones, N. Genes Dev. (1994) [Pubmed]
  4. Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. Versele, M., Thorner, J. J. Cell Biol. (2004) [Pubmed]
  5. The Saccharomyces cerevisiae actin-related protein Arp2 is involved in the actin cytoskeleton. Moreau, V., Madania, A., Martin, R.P., Winson, B. J. Cell Biol. (1996) [Pubmed]
  6. Isolation of the centromere-linked CDC10 gene by complementation in yeast. Clarke, L., Carbon, J. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  7. Characterization of the CDC10 product and the timing of events of the budding site of Saccharomyces cerevisiae. Jeong, J.W., Kim, D.H., Choi, S.Y., Kim, H.B. Mol. Cells (2001) [Pubmed]
  8. Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. Mori, T., Miura, K., Fujiwara, T., Shin, S., Inazawa, J., Nakamura, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
  9. Molecular cloning of Saccharomyces cerevisiae CDC6 gene. Isolation, identification, and sequence analysis. Zhou, C., Huang, S.H., Jong, A.Y. J. Biol. Chem. (1989) [Pubmed]
  10. Cell integrity and morphogenesis in a budding yeast septin mutant. Cid, V.J., Adamíková, L., Cenamor, R., Molina, M., Sánchez, M., Nombela, C. Microbiology (Reading, Engl.) (1998) [Pubmed]
  11. Saccharomyces cerevisiae exhibits a sporulation-specific temporal pattern of transcript accumulation. Kaback, D.B., Feldberg, L.R. Mol. Cell. Biol. (1985) [Pubmed]
  12. Components required for cytokinesis are important for bud site selection in yeast. Flescher, E.G., Madden, K., Snyder, M. J. Cell Biol. (1993) [Pubmed]
  13. Homologs of the yeast neck filament associated genes: isolation and sequence analysis of Candida albicans CDC3 and CDC10. DiDomenico, B.J., Brown, N.H., Lupisella, J., Greene, J.R., Yanko, M., Koltin, Y. Mol. Gen. Genet. (1994) [Pubmed]
  14. E2F site activates transcription in fission yeast Schizosaccharomyces pombe and binds to a 30-kDa transcription factor. Malhotra, P., Manohar, C.F., Swaminathan, S., Toyama, R., Dhar, R., Reichel, R., Thimmapaya, B. J. Biol. Chem. (1993) [Pubmed]
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