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SPBC115.02c  -  AFG1 family mitochondrial ATPase (predicted)

Schizosaccharomyces pombe 972h-

 
 
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High impact information on SPBC115.02c

 

Biological context of SPBC115.02c

  • I propose that the plasma membrane Mg2+-dependent ATPase in yeast cells not only carries out electrogenic H+ ejection but also drives the uptake of potassium via a voltage-sensitive gate which is closed in the absence and open in the presence of the membrane potential [6].
  • Electrogenic proton translocation coupled to ATP hydrolysis by the plasma membrane Mg2+-dependent ATPase of yeast in reconstituted proteoliposomes [7].
  • In the yeast Schizosaccharomyces pombe, the structural gene mutations A23-13 (alpha-) and B59-1 (beta-) which totally prevent the expression of either the alpha or the beta subunits of the mitochondrial ATPase, were shown by classical genetic mapping studies to be both located on chromosome I but genetically unlinked [8].
  • A close correlation is observed between the pH dependence of the intrinsic fluorescence and the pH dependence of (i) ATPase activity, (ii) the fluorescence of Tb-formycin triphosphate bound to the active site, and (iii) inhibition by vanadate of ATPase activity [9].
  • These results suggest that in these conditions, the target of Dio-9 is not the mitochondrial ATPase but a plasma membrane proton-translocating function generating an electrochemical gradient required for active transport [10].
 

Anatomical context of SPBC115.02c

 

Associations of SPBC115.02c with chemical compounds

  • In this report, we show that, as in the case of other P-type ATPase, the purified enzyme exhibits a p-nitrophenylphosphatase activity which can be completely inhibited by vanadate [16].
  • Two mutations involved a defective ATPase activity and the inability to grow on glycerol (gly) [8].
  • In the presence of antimycin A, specific mitochondrial ATPase inhibitors such as venruricidin A do not inhibit metabolite uptakes and their stimulation by adenosine 3':5'-monophosphate [10].
  • The phospholipid distribution in the sucrose gradient indicates that inactivation of the ATPase may result from the partial delipidation occurring during purification [17].
  • The mutant pma1-2 ATPase activity is markedly stimulated by 10-20% dimethyl sulfoxide, which has a limited effect on the wild type and pma1-1 enzymes [18].
 

Other interactions of SPBC115.02c

 

Analytical, diagnostic and therapeutic context of SPBC115.02c

References

  1. The endoplasmic reticulum cation P-type ATPase Cta4p is required for control of cell shape and microtubule dynamics. Façanha, A.L., Appelgren, H., Tabish, M., Okorokov, L., Ekwall, K. J. Cell Biol. (2002) [Pubmed]
  2. Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51(+) from Schizosaccharomyces pombe. Shim, Y.S., Jang, Y.K., Lim, M.S., Lee, J.S., Seong, R.H., Hong, S.H., Park, S.D. Mol. Cell. Biol. (2000) [Pubmed]
  3. The EB1 homolog Mal3 stimulates the ATPase of the kinesin Tea2 by recruiting it to the microtubule. Browning, H., Hackney, D.D. J. Biol. Chem. (2005) [Pubmed]
  4. The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes. Hartmann-Petersen, R., Wallace, M., Hofmann, K., Koch, G., Johnsen, A.H., Hendil, K.B., Gordon, C. Curr. Biol. (2004) [Pubmed]
  5. Transport of metal-binding peptides by HMT1, a fission yeast ABC-type vacuolar membrane protein. Ortiz, D.F., Ruscitti, T., McCue, K.F., Ow, D.W. J. Biol. Chem. (1995) [Pubmed]
  6. Potassium transport coupled to ATP hydrolysis in reconstituted proteoliposomes of yeast plasma membrane ATPase. Villalobo, A. J. Biol. Chem. (1982) [Pubmed]
  7. Electrogenic proton translocation coupled to ATP hydrolysis by the plasma membrane Mg2+-dependent ATPase of yeast in reconstituted proteoliposomes. Villalobo, A., Boutry, M., Goffeau, A. J. Biol. Chem. (1981) [Pubmed]
  8. Independent loci for the structural genes of the yeast mitochondrial alpha and beta ATPase subunits. Vassarotti, A., Boutry, M., Colson, A.M., Goffeau, A. J. Biol. Chem. (1984) [Pubmed]
  9. The yeast plasma membrane H(+)-ATPase. An essential change of conformation triggered by H+. Blanpain, J.P., Ronjat, M., Supply, P., Dufour, J.P., Goffeau, A., Dupont, Y. J. Biol. Chem. (1992) [Pubmed]
  10. Stimulation of active uptake of nucleosides and amino acids by cyclic adenosine 3' :5'-monophosphate in the yeast Schizosaccharomyces pombe. Foury, F., Goffeau, A. J. Biol. Chem. (1975) [Pubmed]
  11. A single mutation confers vanadate resistance to the plasma membrane H+-ATPase from the yeast Schizosaccharomyces pombe. Ulaszewski, S., Van Herck, J.C., Dufour, J.P., Kulpa, J., Nieuwenhuis, B., Goffeau, A. J. Biol. Chem. (1987) [Pubmed]
  12. Fission yeast pkl1 is a kinesin-related protein involved in mitotic spindle function. Pidoux, A.L., LeDizet, M., Cande, W.Z. Mol. Biol. Cell (1996) [Pubmed]
  13. Complementation of a Schizosaccharomyces pombe mutant lacking the beta subunit of the mitochondrial ATPase by the ATP2 gene of Saccharomyces cerevisiae. Boutry, M., Douglas, M.G. J. Biol. Chem. (1983) [Pubmed]
  14. Mitochondrial adenosine triphosphatase of the fission yeast, Schizosaccharomyces pombe 972h-. Changes in activity and inhibitor-sensitivity in response to catabolite repression. Lloyd, D., Edwards, S.W. Biochem. J. (1976) [Pubmed]
  15. Characterization of the ATPase and GTPase activities of elongation factor 3 (EF-3) purified from yeasts. Uritani, M., Miyazaki, M. J. Biochem. (1988) [Pubmed]
  16. p-nitrophenylphosphatase activity of plasma membrane H(+)-ATPase from yeast. Implications for the regulation of the catalytic cycle by H+. Ferreira-Pereira, A., Alves-Ferreira, M., de Carvalho-Alves, P.C. J. Biol. Chem. (1994) [Pubmed]
  17. Phospholipid reactivation of the purified plasma membrane ATPase of yeast. Dufour, J.P., Goffeau, A. J. Biol. Chem. (1980) [Pubmed]
  18. Effects of phosphate and hydrophobic molecules on two mutations in the beta-strand sector of the H(+)-ATPase from the yeast plasma membrane. Goffeau, A., de Meis, L. J. Biol. Chem. (1990) [Pubmed]
  19. Calcium homeostasis and transport are affected by disruption of cta3, a novel gene encoding Ca2(+)-ATPase in Schizosaccharomyces pombe. Ghislain, M., Goffeau, A., Halachmi, D., Eilam, Y. J. Biol. Chem. (1990) [Pubmed]
  20. Fission yeast hrp1, a chromodomain ATPase, is required for proper chromosome segregation and its overexpression interferes with chromatin condensation. Yoo, E.J., Jin, Y.H., Jang, Y.K., Bjerling, P., Tabish, M., Hong, S.H., Ekwall, K., Park, S.D. Nucleic Acids Res. (2000) [Pubmed]
  21. A new mutation for multiple drug resistance and modified plasma membrane ATPase activity in Schizosaccharomyces pombe. Ulaszewski, S., Coddington, A., Goffeau, A. Curr. Genet. (1986) [Pubmed]
  22. Functional expression of the ENA1(PMR2)-ATPase of Saccharomyces cerevisiae in Schizosaccharomyces pombe. Bañuelos, M.A., Quintero, F.J., Rodríguez-Navarro, A. Biochim. Biophys. Acta (1995) [Pubmed]
  23. TFIIH XPB mutants suggest a unified bacterial-like mechanism for promoter opening but not escape. Lin, Y.C., Choi, W.S., Gralla, J.D. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  24. Solubilization by lysolecithin and purification of the plasma membrane ATPase of the yeast Schizosaccharomyces pombe. Dufour, J.P., Goffeau, A. J. Biol. Chem. (1978) [Pubmed]
 
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