Disease relevance of CDC16

• TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas [1].
• Group III rats were treated with intravenous APC 6 hours after induction of pancreatitis [2].

High impact information on CDC16

• CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition [3].
• We find that the CDC27Hs and CDC16Hs proteins colocalize to the centrosome at all stages of the mammalian cell cycle, and to the mitotic spindle [3].
• TBC (Tre-2/Bub2/Cdc16) domains are predicted to encode GTPase-activating proteins (GAPs) for Rab family G proteins [4].
• Deletion analysis suggests that the site of binding to PP5 is localized to the COOH-terminal block of tetratricopeptide repeats in CDC16 and CDC27 [5].
• When pheromone arrested cells of cdc16 and cdc23 mutants were shifted to the restrictive temperature, they underwent DNA replication in the presence of pheromone [6].

Biological context of CDC16

• We conclude that CDC27 and CDC16 are evolutionarily conserved components of the centrosome and mitotic spindle that control the onset of postmetaphase events during mitosis [3].
• Three of the eight subunits of the anaphase-promoting complex (CDC16, CDC23, and CDC27) have been shown to be phosphorylated in M phase, and their phosphorylation is required for the anaphase-promoting complex to be active as a ubiquitin ligase [5].
• When using either PB13 or CDC16 cDNA as probes, similar radiation-induced alterations in gene expression were observed [7].
• Down-regulation of the human CDC16 gene after exposure to ionizing radiation: a possible role in the radioadaptive response [7].
• Expression of the CDC16 gene was also repressed after oxidative stress with H(2)O(2) [7].

Other interactions of CDC16

• TBC1D1 is the founding member of a family of related proteins with homology to tre-2/UPS6, BUB2, and cdc16 and containing the tbc box motif of 180-220 amino acids [8].

References