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Gene Review

CDC16  -  cell division cycle 16

Homo sapiens

Synonyms: ANAPC6, APC6, Anaphase-promoting complex subunit 6, CDC16 homolog, CDC16Hs, ...
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Disease relevance of CDC16


High impact information on CDC16

  • CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition [3].
  • We find that the CDC27Hs and CDC16Hs proteins colocalize to the centrosome at all stages of the mammalian cell cycle, and to the mitotic spindle [3].
  • TBC (Tre-2/Bub2/Cdc16) domains are predicted to encode GTPase-activating proteins (GAPs) for Rab family G proteins [4].
  • Deletion analysis suggests that the site of binding to PP5 is localized to the COOH-terminal block of tetratricopeptide repeats in CDC16 and CDC27 [5].
  • When pheromone arrested cells of cdc16 and cdc23 mutants were shifted to the restrictive temperature, they underwent DNA replication in the presence of pheromone [6].

Biological context of CDC16


Other interactions of CDC16

  • TBC1D1 is the founding member of a family of related proteins with homology to tre-2/UPS6, BUB2, and cdc16 and containing the tbc box motif of 180-220 amino acids [8].


  1. TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Yasui, K., Arii, S., Zhao, C., Imoto, I., Ueda, M., Nagai, H., Emi, M., Inazawa, J. Hepatology (2002) [Pubmed]
  2. The effect of activated protein C on experimental acute necrotizing pancreatitis. Yamenel, L., Mas, M.R., Comert, B., Isik, A.T., Aydin, S., Mas, N., Deveci, S., Ozyurt, M., Tasci, I., Unal, T. Critical care (London, England) (2005) [Pubmed]
  3. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Tugendreich, S., Tomkiel, J., Earnshaw, W., Hieter, P. Cell (1995) [Pubmed]
  4. The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. Martinu, L., Masuda-Robens, J.M., Robertson, S.E., Santy, L.C., Casanova, J.E., Chou, M.M. Mol. Cell. Biol. (2004) [Pubmed]
  5. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. Ollendorff, V., Donoghue, D.J. J. Biol. Chem. (1997) [Pubmed]
  6. The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase. Irniger, S., Nasmyth, K. J. Cell. Sci. (1997) [Pubmed]
  7. Down-regulation of the human CDC16 gene after exposure to ionizing radiation: a possible role in the radioadaptive response. Zhou, P.K., Rigaud, O. Radiat. Res. (2001) [Pubmed]
  8. The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. White, R.A., Pasztor, L.M., Richardson, P.M., Zon, L.I. Cytogenet. Cell Genet. (2000) [Pubmed]
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