Disease relevance of sxa2

• Loss of function of the sxa2 gene in M cells causes hypersensitivity to the P-factor mating pheromone and a reduction in mating efficiency [1].

High impact information on sxa2

• Combination of the cyr1 and sxa2 mutations enhanced this susceptibility [2].
• We cloned the Schizosaccharomyces pombe map1 gene by virtue of its ability to stimulate transcription of the sxa2 gene, which encodes a carboxypeptidase expressed specifically in h- cells in response to mating-pheromone signaling [3].
• Schizosaccharomyces pombe sxa1+ and sxa2+ encode putative proteases involved in the mating response [4].
• Production of the carboxypeptidase requires a functional sxa2 gene [5].
• Here we demonstrate the secretion of an sxa2-dependent carboxypeptidase that inactivates P-factor by removal of the C-terminal leucine residue [1].

Biological context of sxa2

• The gene products of sxa1 and sxa2, as deduced from their nucleotide sequences, were homologous to aspartyl proteases and serine carboxypeptidases, respectively [4].

Other interactions of sxa2

• However, genetic evidence suggested that the sxa1 and sxa2 gene products are not directly involved in the Ras1 pathway [4].

References