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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

rhp57  -  RecA family ATPase Rhp57

Schizosaccharomyces pombe 972h-

 
 
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High impact information on rhp57

  • Furthermore, the lethality of a rad60-1 rqh1Delta double mutant was suppressed by the deletion of rhp51 or rhp57 [1].
  • We have found that loss of the HR genes rhp55(+) or rhp57(+), but not rhp51(+) or rhp54(+), suppresses the HU sensitivity of Deltarqh1 cells [2].
  • An rhp57 (RAD57 homolog of S. pombe) deletion strain was more sensitive to MMS, UV, and gamma-rays than the wild-type strain and showed a reduction in the frequency of mitotic homologous recombination [3].
  • Further, we found that Deltasrs2 Deltarqh1 slow growth is related to recombination, as loss of either the rhp51+ or rhp57+ recombination genes improves cell growth in the double mutant [4].

References

  1. Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest. Miyabe, I., Morishita, T., Hishida, T., Yonei, S., Shinagawa, H. Mol. Cell. Biol. (2006) [Pubmed]
  2. A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe. Hope, J.C., Maftahi, M., Freyer, G.A. Genetics (2005) [Pubmed]
  3. A recombination repair gene of Schizosaccharomyces pombe, rhp57, is a functional homolog of the Saccharomyces cerevisiae RAD57 gene and is phylogenetically related to the human XRCC3 gene. Tsutsui, Y., Morishita, T., Iwasaki, H., Toh, H., Shinagawa, H. Genetics (2000) [Pubmed]
  4. The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes. Maftahi, M., Hope, J.C., Delgado-Cruzata, L., Han, C.S., Freyer, G.A. Nucleic Acids Res. (2002) [Pubmed]
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