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Gene Review:

XRCC3 - X-ray repair complementing defective...

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Sz??ts, D. et al., Raaphorst, G.P. et al., Henry-Mowatt, J. et al., Danoy, P. et al.

Raaphorst, Leblanc, Li,

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High impact information on XRCC3

Fork slowing is reduced or absent in irs1SF CHO cells and XRCC3(-/-) chicken DT40 cells, indicating that fork slowing is an active process that requires the homologous recombination protein XRCC3 [1].
Blocking an early stage of the recombination reaction by disruption of XRCC3 not only suppresses immunoglobulin gene conversion but also prevents the aberrant immunoglobulin gene rearrangements associated with RAD18 deficiency, reverses the elevated sister chromatid exchange of the rad18 mutant, and reduces its sensitivity to DNA damage [2].
We established mutant cell lines complemented with either wild-type or variant cDNAs of three human genes, RAD51, XRCC2, and XRCC3, and assessed their sensitivity to cisplatin and mitomycin C [3].

Anatomical context of XRCC3

The mutation of the homologous recombination repair (HR) pathway through XRCC3 in CHO cells resulted in increased radiation and cisplatin sensitivity and to a lesser extent for the Rad54 knockout in the DT40 chicken cells [4].

References

XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Henry-Mowatt, J., Jackson, D., Masson, J.Y., Johnson, P.A., Clements, P.M., Benson, F.E., Thompson, L.H., Takeda, S., West, S.C., Caldecott, K.W. Mol. Cell (2003) [Pubmed]
Role for RAD18 in Homologous Recombination in DT40 Cells. Sz??ts, D., Simpson, L.J., Kabani, S., Yamazoe, M., Sale, J.E. Mol. Cell. Biol. (2006) [Pubmed]
A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage. Danoy, P., Sonoda, E., Lathrop, M., Takeda, S., Matsuda, F. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
A comparison of response to cisplatin, radiation and combined treatment for cells deficient in recombination repair pathways. Raaphorst, G.P., Leblanc, M., Li, L.F. Anticancer Res. (2005) [Pubmed]

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AgaP_AGAP013180	Anopheles gambiae str. PEST
XRCC3	Arabidopsis thaliana
XRCC3	Bos taurus
XRCC3	Canis lupus familiaris
xrcc3	Danio rerio
spn-B	Drosophila melanogaster
XRCC3	Homo sapiens
XRCC3	Macaca mulatta
MGG_06985	Magnaporthe oryzae 70-15
Xrcc3	Mus musculus
NCU01771	Neurospora crassa OR74A
Os02g0562100	Oryza sativa Japonica Group
XRCC3	Pan troglodytes
LOC102551085	Rattus norvegicus
rhp57	Schizosaccharomyces pombe 972h-
xrcc3	Xenopus (Silurana) tropicalis

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