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XRCC3  -  X-ray repair complementing defective...

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High impact information on XRCC3

 

Anatomical context of XRCC3

  • The mutation of the homologous recombination repair (HR) pathway through XRCC3 in CHO cells resulted in increased radiation and cisplatin sensitivity and to a lesser extent for the Rad54 knockout in the DT40 chicken cells [4].

References

  1. XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Henry-Mowatt, J., Jackson, D., Masson, J.Y., Johnson, P.A., Clements, P.M., Benson, F.E., Thompson, L.H., Takeda, S., West, S.C., Caldecott, K.W. Mol. Cell (2003) [Pubmed]
  2. Role for RAD18 in Homologous Recombination in DT40 Cells. Sz??ts, D., Simpson, L.J., Kabani, S., Yamazoe, M., Sale, J.E. Mol. Cell. Biol. (2006) [Pubmed]
  3. A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage. Danoy, P., Sonoda, E., Lathrop, M., Takeda, S., Matsuda, F. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  4. A comparison of response to cisplatin, radiation and combined treatment for cells deficient in recombination repair pathways. Raaphorst, G.P., Leblanc, M., Li, L.F. Anticancer Res. (2005) [Pubmed]
 
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