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Gene Review

rhp51  -  RecA family recombinase Rhp51

Schizosaccharomyces pombe 972h-

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Disease relevance of rhp51


High impact information on rhp51

  • Rhp55 was required for interchromosomal gene conversion; however, an alternative DSB repair mechanism was used in an rhp55Delta background involving ku70(+) and rhp51(+) [2].
  • Furthermore, the lethality of a rad60-1 rqh1Delta double mutant was suppressed by the deletion of rhp51 or rhp57 [3].
  • The deletion of rhp51 suppressed the aberrant mitosis of rad60-1 cells and caused mitotic arrest [3].
  • The gene that complements the MMS sensitivity of this mutant was cloned and designated rad60. rad60 encodes a protein with 406 amino acids which has the conserved ubiquitin-2 motif found in ubiquitin family proteins. rad60-1 is hypersensitive to UV and gamma rays, epistatic to rhp51, and defective in the repair of DSBs caused by gamma-irradiation [4].
  • The MMS sensitivity was more severe at lower temperature and was suppressed by the presence of a multicopy plasmid bearing the rhp51 gene [5].

Biological context of rhp51


  1. Gain- and loss-of-function of Rhp51, a Rad51 homolog in fission yeast, reveals dissimilarities in chromosome integrity. Kim, W.J., Lee, H., Park, E.J., Park, J.K., Park, S.D. Nucleic Acids Res. (2001) [Pubmed]
  2. Pathway utilization in response to a site-specific DNA double-strand break in fission yeast. Prudden, J., Evans, J.S., Hussey, S.P., Deans, B., O'Neill, P., Thacker, J., Humphrey, T. EMBO J. (2003) [Pubmed]
  3. Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest. Miyabe, I., Morishita, T., Hishida, T., Yonei, S., Shinagawa, H. Mol. Cell. Biol. (2006) [Pubmed]
  4. The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand DNA breaks spontaneously occurring during replication and induced by DNA-damaging agents. Morishita, T., Tsutsui, Y., Iwasaki, H., Shinagawa, H. Mol. Cell. Biol. (2002) [Pubmed]
  5. A recombination repair gene of Schizosaccharomyces pombe, rhp57, is a functional homolog of the Saccharomyces cerevisiae RAD57 gene and is phylogenetically related to the human XRCC3 gene. Tsutsui, Y., Morishita, T., Iwasaki, H., Toh, H., Shinagawa, H. Genetics (2000) [Pubmed]
  6. Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer. Kibe, T., Tomita, K., Matsuura, A., Izawa, D., Kodaira, T., Ushimaru, T., Uritani, M., Ueno, M. Nucleic Acids Res. (2003) [Pubmed]
  7. Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe. Memisoglu, A., Samson, L. J. Bacteriol. (2000) [Pubmed]
  8. Regulation of DNA damage inducible rhp51+ gene, a rec A homolog from Schizosaccharomyces pombe. Park, S.D., Jin, Y.H., Jang, Y.K. The Journal of toxicological sciences. (1998) [Pubmed]
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