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Gene Review

Xrcc3  -  X-ray repair complementing defective...

Mus musculus

Synonyms: 4432412E01Rik, AI182522, AW537713, DNA repair protein XRCC3, X-ray repair cross-complementing protein 3
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High impact information on Xrcc3

  • These paralogs form two complexes (Rad51C/Xrcc3 and Rad51B/C/D/Xrcc2), which play roles in somatic recombination, DNA repair and chromosome stability [1].
  • Moreover, the atrad51c-1 mutant is the only one of these to show meiotic defects similar to those of the atxrcc3 mutant, and thus only the Rad51C/Xrcc3 complex is required to achieve meiosis [1].

Analytical, diagnostic and therapeutic context of Xrcc3

  • Using yeast two-hybrid and co-immunoprecipitation techniques, we have demonstrated that a fragment of Rad51B containing amino acid residues 1-75 interacts with the C-terminus and linker of Rad51C, residues 79-376, and this region of Rad51C also interacts with mRad51D and Xrcc3 [2].


  1. Differing requirements for the Arabidopsis Rad51 paralogs in meiosis and DNA repair. Bleuyard, J.Y., Gallego, M.E., Savigny, F., White, C.I. Plant J. (2005) [Pubmed]
  2. Domain mapping of the Rad51 paralog protein complexes. Miller, K.A., Sawicka, D., Barsky, D., Albala, J.S. Nucleic Acids Res. (2004) [Pubmed]
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