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Gene Review:

spn-B - spindle B

Drosophila melanogaster

Synonyms: CG3325, Dmel\CG3325, Rad51, Rad51-like, Spn-B, ...

Abdu, U. et al., Sakoyama, Y. et al., Ghabrial, A. et al.

Sakoyama, Mizuta, Fukunaga, Michinomae, Smith,

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High impact information on spn-B

In contrast, spnB and spnD appear to be required only in meiosis [1].
okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis [1].
In Drosophila, mutations in double-strand DNA break (DSB) repair enzymes, such as spn-B, activate a meiotic checkpoint leading to dorsal-ventral patterning defects in the egg and an abnormal appearance of the oocyte nucleus [2].
We have cloned a novel Drosophila melanogaster homeobox (Hbox) containing gene, NK-7.1 (Dm.HboxNK-7.1), which is located at 88B3 on the chromosome map, and is 1.5 kb downstream of the spn-B gene [3].

Biological context of spn-B

Mutations in spn-D cause an array of ovarian phenotypes similar to spn-B [2].

References

okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Ghabrial, A., Ray, R.P., Schüpbach, T. Genes Dev. (1998) [Pubmed]
The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis. Abdu, U., González-Reyes, A., Ghabrial, A., Schüpbach, T. Genetics (2003) [Pubmed]
Cloning of a novel homeobox (NK-7.1) containing gene, DmHboxNK-7.1, from Drosophila melanogaster. Sakoyama, Y., Mizuta, I., Fukunaga, A., Michinomae, M., Smith, P.R. Biochem. Genet. (2002) [Pubmed]

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