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Gene Review:

scd1 - RhoGEF Scd1

Schizosaccharomyces pombe 972h-

Li, Y.C. et al., Chang, E.C. et al., Song, K. et al., Li, Y. et al., Papadaki, P. et al.

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Disease relevance of scd1

In this study, we demonstrated that the scd1 deletion (scd1Delta) induced hypersensitivity to microtubule destabilizing drugs and instability of the minichromosome [1].

High impact information on scd1

Studies with the yeast two-hybrid system indicate that scd2 forms complexes with both scd1 and cdc42sp [2].
The inhibition of cytokinesis by byr4 overexpression was exacerbated by null alleles of ras1 and scd1, suggesting a link between pathways needed for cell polarity and cytokinesis [3].
Like ras1 Delta and scd1 Delta, efc25 Delta is synthetically lethal with a deletion in tea1, a critical element for cell polarity control [4].
We showed that klp5 or klp6 inactivation in combination with the scd1 deletion (scd1delta) created a synthetic temperature-dependent growth defect [5].
Overexpression of scd1 induced formation of abnormal spindles and chromosome missegregation [1].

Other interactions of scd1

Furthermore, biochemical studies indicate that the interaction between scd1 and scd2 is direct [2].

References

Fission yeast Ras1 effector Scd1 interacts with the spindle and affects its proper formation. Li, Y.C., Chen, C.R., Chang, E.C. Genetics (2000) [Pubmed]
Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Chang, E.C., Barr, M., Wang, Y., Jung, V., Xu, H.P., Wigler, M.H. Cell (1994) [Pubmed]
A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis. Song, K., Mach, K.E., Chen, C.Y., Reynolds, T., Albright, C.F. J. Cell Biol. (1996) [Pubmed]
Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. Papadaki, P., Pizon, V., Onken, B., Chang, E.C. Mol. Cell. Biol. (2002) [Pubmed]
Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis. Li, Y., Chang, E.C. Genetics (2003) [Pubmed]

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AGOS_ADR388C	Ashbya gossypii ATCC 10895
KLLA0C12969g	Kluyveromyces lactis NRRL Y-1140
CDC24	Saccharomyces cerevisiae S288c

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