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Gene Review

ras1  -  GTPase Ras1

Schizosaccharomyces pombe 972h-

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High impact information on ras1


Biological context of ras1


Anatomical context of ras1

  • Among low-molar-mass species, a component moving as a band at 31 kDa was conspicuous in ras1- cell walls [8].

Regulatory relationships of ras1

  • By Northern analysis of RNA preparations from strains carrying wild-type or mutant ras1 alleles and grown to different stages of the growth cycle, we have shown that ras1 plays an important role in inducing the Pi transcript of the mating-type loci and the mei3 gene transcript [6].

Other interactions of ras1

  • Several physiological similarities between strains containing null alleles of these genes supports the idea that ras1 and byr1 are functionally closely related [6].
  • Characterization of the Schizosaccharomyces pombe ral2 gene implicated in activation of the ras1 gene product [9].
  • The ste6 gene of Schizosaccharomyces pombe encodes a putative GDP-GTP exchange factor for the ras1 gene product [10].


  1. Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway. Hoffman, C.S., Winston, F. Genes Dev. (1991) [Pubmed]
  2. A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis. Song, K., Mach, K.E., Chen, C.Y., Reynolds, T., Albright, C.F. J. Cell Biol. (1996) [Pubmed]
  3. A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast. Nadin-Davis, S.A., Nasim, A. EMBO J. (1988) [Pubmed]
  4. Two types of RAS mutants that dominantly interfere with activators of RAS. Jung, V., Wei, W., Ballester, R., Camonis, J., Mi, S., Van Aelst, L., Wigler, M., Broek, D. Mol. Cell. Biol. (1994) [Pubmed]
  5. Schizosaccharomyces pombe sxa1+ and sxa2+ encode putative proteases involved in the mating response. Imai, Y., Yamamoto, M. Mol. Cell. Biol. (1992) [Pubmed]
  6. Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes. Nadin-Davis, S.A., Nasim, A. Mol. Cell. Biol. (1990) [Pubmed]
  7. byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Wang, Y., Xu, H.P., Riggs, M., Rodgers, L., Wigler, M. Mol. Cell. Biol. (1991) [Pubmed]
  8. Changes in cell wall composition of deformed ras1- cells of Schizosaccharomyces pombe. Harmouch, N., Pichová, A., Coulon, J., Streiblová, E., Bonaly, R. Folia Microbiol. (Praha) (1995) [Pubmed]
  9. Characterization of the Schizosaccharomyces pombe ral2 gene implicated in activation of the ras1 gene product. Fukui, Y., Miyake, S., Satoh, M., Yamamoto, M. Mol. Cell. Biol. (1989) [Pubmed]
  10. Transcriptional regulation of a Ras nucleotide-exchange factor gene by extracellular signals in fission yeast. Hughes, D.A., Yabana, N., Yamamoto, M. J. Cell. Sci. (1994) [Pubmed]
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