The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

fbp1  -  fructose-1,6-bisphosphatase Fbp1

Schizosaccharomyces pombe 972h-

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on fbp1

 

Biological context of fbp1

  • We conclude that the PKA and MAPK signal transduction pathways regulate fbp1 transcription at UAS1 and UAS2, but that the antagonistic interactions between these pathways involve different mechanisms at each site [3].
 

Associations of fbp1 with chemical compounds

  • To study this, we have investigated the transcriptional regulation of the Schizosaccharomyces pombe fbp1 gene that is repressed by a cyclic AMP (cAMP)-dependent protein kinase A (PKA) pathway and is activated by a stress-activated mitogen-activated protein kinase (MAPK) pathway [3].
  • We show that methionine reduces the intracellular cAMP pool and induces the expression of at least two cAMP-repressible genes, including fbp1 and ste11 [4].
 

Regulatory relationships of fbp1

  • Overexpression of pyp1+ inhibits both transcription of the fbp1 gene, which is negatively regulated by a glucose-induced activation of PKA, and sexual development, which is negatively regulated by PKA through a nitrogen- and glucose-monitoring mechanism [5].
 

Other interactions of fbp1

  • Furthermore, disruption of pcr1 reduced expression of fbp1, a glucose-repressible gene negatively regulated by PKA [6].
  • We show that pyp1 repression of fbp1 transcription is independent of wee1 [5].
  • Cells deleted for git11 are defective in glucose repression of both fbp1 transcription and sexual development, resembling cells lacking either the gpa2 Galpha or the git5 Gbeta [7].
  • Expression of the fbp1 gene is negatively regulated by cAMP in response to glucose limitation: induction of fbp1 also requires wis1 and sty1 function [8].

References

  1. Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway. Hoffman, C.S., Winston, F. Genes Dev. (1991) [Pubmed]
  2. Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast. Higuchi, T., Watanabe, Y., Yamamoto, M. Mol. Cell. Biol. (2002) [Pubmed]
  3. Protein kinase A and mitogen-activated protein kinase pathways antagonistically regulate fission yeast fbp1 transcription by employing different modes of action at two upstream activation sites. Neely, L.A., Hoffman, C.S. Mol. Cell. Biol. (2000) [Pubmed]
  4. Methionine induces sexual development in the fission yeast Schizosaccharomyces pombe via an ste11-dependent signalling pathway. Schweingruber, A.M., Hilti, N., Edenharter, E., Schweingruber, M.E. J. Bacteriol. (1998) [Pubmed]
  5. The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways. Dal Santo, P., Blanchard, B., Hoffman, C.S. J. Cell. Sci. (1996) [Pubmed]
  6. Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development. Watanabe, Y., Yamamoto, M. Mol. Cell. Biol. (1996) [Pubmed]
  7. The git5 Gbeta and git11 Ggamma form an atypical Gbetagamma dimer acting in the fission yeast glucose/cAMP pathway. Landry, S., Hoffman, C.S. Genetics (2001) [Pubmed]
  8. The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast. Stettler, S., Warbrick, E., Prochnik, S., Mackie, S., Fantes, P. J. Cell. Sci. (1996) [Pubmed]
 
WikiGenes - Universities