High impact information on cdr1

• Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer [1].
• These results show that nim1/cdr1 functions as a positive regulator of mitosis by directly phosphorylating and inactivating the mitotic inhibitor Wee1 [2].
• Genetics indicate that the mitotic inducer nim1/cdr1 acts upstream of wee1, possibly as a negative regulator of wee1 (refs 10, 11) [2].
• Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase [2].
• Deletion of cdr2 causes a G2-M delay that is more severe than that caused by nim1/cdr1 mutations [3].

Biological context of cdr1

• Genetic studies have suggested that the nim1 protein kinase (also known as cdr1) acts as a positive regulator of mitosis by down-regulating the wee1 pathway in yeast cells [1].
• Antagonism of chk1 signaling in the g2 DNA damage checkpoint by dominant alleles of cdr1 [4].
• The cdr1 gene in Schizosaccharomyces pombe was identified as a mutation affecting the nutritional responsiveness of the mitotic size control. cdr1 alleles have been further analyzed for genetic interactions with elements of the mitotic control pathway and cloned by plasmid rescue of a conditional lethal cdr1-76 cdc25-22 double mutant [5].
• The nim1/cdr1 protein kinase is required for an efficient adaptation of cell cycle parameters to changes in nutritional conditions [6].
• Dm cDNAs capable of complementing the temperature-sensitive phenotype of a nim1/cdr1 cdc25 double mutant strain were identified and found to fall into two classes [7].

Enzymatic interactions of cdr1

• The fission yeast cdr1/nim1 protein kinase phosphorylates and inactivates the weel cdc2-inhibitory kinase [8].

References