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Gene Review

CCDC110  -  coiled-coil domain containing 110

Homo sapiens

Synonyms: CT52, Cancer/testis antigen 52, Cancer/testis antigen KM-HN-1, Coiled-coil domain-containing protein 110, KM-HN-1, ...
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Disease relevance of CCDC110


High impact information on CCDC110

  • KM-HN-1 expression was observed in various cancer tissues and cancer cell lines at both mRNA and protein levels [1].
  • The CTL lines specific to KM-HN-1, generated from HLA-A*2402-positive healthy donors and cancer patients, killed human leukocyte antigen (HLA)-A24-positive cancer cells expressing KM-HN-1 but not cell lines that did not express either KM-HN-1 or HLA-A24 [1].
  • Experimental Design and RESULTS: We identified a novel gene designated KM-HN-1 the expression of which is testis-specific among normal tissues; it contains coiled coil domains and a leucine zipper motif and encodes a putative protein consisting of 833 amino acids [1].

Analytical, diagnostic and therapeutic context of CCDC110


  1. Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses. Monji, M., Nakatsura, T., Senju, S., Yoshitake, Y., Sawatsubashi, M., Shinohara, M., Kageshita, T., Ono, T., Inokuchi, A., Nishimura, Y. Clin. Cancer Res. (2004) [Pubmed]
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