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Gene Review

Prkaca  -  protein kinase, cAMP-dependent, catalytic,...

Rattus norvegicus

Synonyms: Cs-PKA, PKA C-alpha, PKCA1, cAMP-dependent protein kinase catalytic subunit alpha
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High impact information on Prkaca

  • We find in NG108-15/D2 cells and in cultured primary neurons that a brief exposure to saturating concentrations of DOR and CB1 agonists increases cAMP, promotes PKA C alpha translocation and increases cAMP-dependent gene expression [1].
  • The kinase present in the haploid spermatid cytosol that phosphorylates TP2 has been identified to be the sperm-specific isoform of protein kinase A (Cs-PKA) [2].
  • Reverse transcription-PCR analysis indicated that Cs-PKA was present in the haploid spermatids and absent from premeiotic germ cells [2].


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