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Gene Review: 

Prkaca  -  protein kinase, cAMP-dependent, catalytic,...

Rattus norvegicus

Synonyms: Cs-PKA, PKA C-alpha, PKCA1, cAMP-dependent protein kinase catalytic subunit alpha
 
 
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High impact information on Prkaca

  • We find in NG108-15/D2 cells and in cultured primary neurons that a brief exposure to saturating concentrations of DOR and CB1 agonists increases cAMP, promotes PKA C alpha translocation and increases cAMP-dependent gene expression [1].
  • The kinase present in the haploid spermatid cytosol that phosphorylates TP2 has been identified to be the sperm-specific isoform of protein kinase A (Cs-PKA) [2].
  • Reverse transcription-PCR analysis indicated that Cs-PKA was present in the haploid spermatids and absent from premeiotic germ cells [2].

References

  1. Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-beta gamma dimers. Yao, L., Fan, P., Jiang, Z., Mailliard, W.S., Gordon, A.S., Diamond, I. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Phosphorylation of rat spermatidal protein TP2 by sperm-specific protein kinase A and modulation of its transport into the haploid nucleus. Ullas, K.S., Rao, M.R. J. Biol. Chem. (2003) [Pubmed]
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