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Gene Review

pka1  -  cAMP-dependent protein kinase catalytic...

Schizosaccharomyces pombe 972h-

Synonyms: git6, tpk
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High impact information on pka1


Biological context of pka1


Anatomical context of pka1

  • Addition of glucose to starved cyr1 delta cells reduces uptake 9-fold, whereas starved pka1 delta cells, which are able to synthesise cAMP, respond with a 60-fold decrease in transport [11].

Associations of pka1 with chemical compounds


Other interactions of pka1


  1. Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway. Hoffman, C.S., Winston, F. Genes Dev. (1991) [Pubmed]
  2. Crystal structure of casein kinase-1, a phosphate-directed protein kinase. Xu, R.M., Carmel, G., Sweet, R.M., Kuret, J., Cheng, X. EMBO J. (1995) [Pubmed]
  3. Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. DeVoti, J., Seydoux, G., Beach, D., McLeod, M. EMBO J. (1991) [Pubmed]
  4. Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+. Davidson, M.K., Shandilya, H.K., Hirota, K., Ohta, K., Wahls, W.P. J. Biol. Chem. (2004) [Pubmed]
  5. A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development. Kunitomo, H., Higuchi, T., Iino, Y., Yamamoto, M. Mol. Biol. Cell (2000) [Pubmed]
  6. Heat-shock response in Schizosaccharomyces pombe cells lacking cyclic AMP-dependent phosphorylation. Fernández, J., Soto, T., Vicente-Soler, J., Cansado, J., Gacto, M. Curr. Genet. (1997) [Pubmed]
  7. Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Roux, A.E., Quissac, A., Chartrand, P., Ferbeyre, G., Rokeach, L.A. Aging Cell (2006) [Pubmed]
  8. The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast. Stettler, S., Warbrick, E., Prochnik, S., Mackie, S., Fantes, P. J. Cell. Sci. (1996) [Pubmed]
  9. In vivo activation of protein kinase A in Schizosaccharomyces pombe requires threonine phosphorylation at its activation loop and is dependent on PDK1. Tang, Y., McLeod, M. Genetics (2004) [Pubmed]
  10. Identification of sds21 in fission yeast in an inhibitor-resistant high molecular mass protein phosphatase-1 complex. Dawson, J.F., Holmes, C.F. Biochem. Cell Biol. (1999) [Pubmed]
  11. Onset of gluconate-H+ symport in Schizosaccharomyces pombe is regulated by the kinases Wis1 and Pka1, and requires the gti1+ gene product. Caspari, T. J. Cell. Sci. (1997) [Pubmed]
  12. Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe. Byrne, S.M., Hoffman, C.S. J. Cell. Sci. (1993) [Pubmed]
  13. Regulation of mRNA export by nutritional status in fission yeast. Whalen, W.A., Yoon, J.H., Shen, R., Dhar, R. Genetics (1999) [Pubmed]
  14. S. pombe sck2+, a second homologue of S. cerevisiae SCH9 in fission yeast, encodes a putative protein kinase closely related to PKA in function. Fujita, M., Yamamoto, M. Curr. Genet. (1998) [Pubmed]
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