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Gene Review:

PRKACA - protein kinase, cAMP-dependent, catalytic,...

Homo sapiens

Synonyms: PKA C-alpha, PKACA, PKACa, PPNAD4, cAMP-dependent protein kinase catalytic subunit alpha

Taskén, K. et al., Thomas, D.C. et al., Benyo, D.F. et al., Thomis, D.C. et al.

Taskén, Solberg, Zhao, Hansson, Jahnsen, Siciliano,

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High impact information on PRKACA

RNA amplification by polymerase chain reaction revealed that KIN27 C alpha 2 splice-site variant RNA and PKA C alpha RNA were both expressed in the amnion U and HeLa human cell lines [1].
In addition, IFN-gamma treatment increased the ratio of C alpha to C alpha 2 (the two splice-site variants of PKA C alpha subunit mRNA produced in HeLa cells) as measured by a polymerase chain reaction assay [2].
Further, Western immunoblot analyses of the catalytic subunit of PKA (PKA C alpha) in corpora lutea collected throughout the luteal phase revealed immunoreactive protein bands with similar intensities [3].
We have determined the chromosomal localization of the gene for the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) to human chromosome 19 using polymerase chain reaction (PCR) and Southern blot analysis of two different somatic cell hybrid mapping panels [4].
The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1 [4].

References

Mechanism of interferon action. cDNA structure and regulation of a novel splice-site variant of the catalytic subunit of human protein kinase A from interferon-treated human cells. Thomis, D.C., Floyd-Smith, G., Samuel, C.E. J. Biol. Chem. (1992) [Pubmed]
Mechanism of interferon action: alpha and gamma interferons differentially affect mRNA levels of the catalytic subunit of protein kinase A and protein Mx in human cells. Thomas, D.C., Samuel, C.E. J. Virol. (1992) [Pubmed]
Cyclic adenosine monophosphate signaling in the primate corpus luteum: maintenance of protein kinase A activity throughout the luteal phase of the menstrual cycle. Benyo, D.F., Zeleznik, A.J. Endocrinology (1997) [Pubmed]
The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1. Taskén, K., Solberg, R., Zhao, Y., Hansson, V., Jahnsen, T., Siciliano, M.J. Genomics (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_AFL090W	Ashbya gossypii ATCC 10895
PRKACA	Bos taurus
PRKACA	Canis lupus familiaris
prkacab	Danio rerio
KLLA0D03190g	Kluyveromyces lactis NRRL Y-1140
Prkaca	Mus musculus
PRKACA	Pan troglodytes
Prkaca	Rattus norvegicus
TPK2	Saccharomyces cerevisiae S288c
pka1	Schizosaccharomyces pombe 972h-
prkaca	Xenopus (Silurana) tropicalis

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