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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZNF473  -  zinc finger protein 473

Homo sapiens

Synonyms: DKFZP434N043, HZFP100, KIAA1141, ZFP100, ZN473, ...
 
 
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High impact information on ZNF473

  • Antibodies to hZFP100 precipitate U7 snRNA, and expression of hZFP100 in Xenopus oocytes stimulates processing of histone pre-mRNA, showing that hZFP100 is a component of the processing machinery [1].
  • Using a reporter gene that encodes a green fluorescent protein mRNA ending in a histone 3' end and mimics histone gene expression, we demonstrate that ZFP100 is the limiting factor for histone pre-mRNA processing in vivo [2].
  • We previously identified a 100-kDa zinc finger protein (ZFP100) as a component of U7 snRNP that interacts with the SLBP/pre-mRNA complex [3].
  • Of the 18 zinc fingers contained within ZFP100, the region encompassing fingers 2-6 is sufficient to maintain CB localization [3].
  • Here, we show that myc- or GFP-tagged ZFP100 overexpressed after transfection is concentrated in Cajal bodies (CBs), and unlike components of the spliceosomal snRNPs, photobleaching experiments demonstrate that ZFP100 is stably associated with CBs [3].

References

  1. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Dominski, Z., Erkmann, J.A., Yang, X., Sànchez, R., Marzluff, W.F. Genes Dev. (2002) [Pubmed]
  2. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Wagner, E.J., Marzluff, W.F. Mol. Cell. Biol. (2006) [Pubmed]
  3. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. Wagner, E.J., Ospina, J.K., Hu, Y., Dundr, M., Matera, A.G., Marzluff, W.F. RNA (2006) [Pubmed]
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