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Gene Review:

Klk8 - kallikrein related-peptidase 8

Mus musculus

Synonyms: BSP1, Kallikrein-8, NP, Neuropsin, Nrpn, ...

Davies, B. et al., Davies, B.J. et al., Yoshida, S. et al., Wong, G.W. et al.

Yoshida, Hirata, Inoue, Shiosaka,

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High impact information on Klk8

Although BSP2 is expressed in several brain regions, BSP1 expression is strikingly restricted to hippocampus [1].
Mouse mast cells express the tryptic protease neuropsin/Prss19 [2].
Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity [3].
In view of the regional selectivity of BSP1/neuropsin brain expression, the observed phenotype may selectively reflect limbic function, further implicating the hippocampus and amygdala in controlling cortical activation [3].

Biological context of Klk8

Assignment of the neuropsin gene (Prss19) to mouse chromosome band 7B4 by in situ hybridization [4].

Anatomical context of Klk8

Within the hippocampus, our data suggest that BSP1/neuropsin, unlike other serine proteases, has little effect on physiological synaptic remodeling and instead plays a role in limiting neuronal hyperexcitability induced by epileptogenic insult [3].

References

Serine proteases in rodent hippocampus. Davies, B.J., Pickard, B.S., Steel, M., Morris, R.G., Lathe, R. J. Biol. Chem. (1998) [Pubmed]
Mouse mast cells express the tryptic protease neuropsin/Prss19. Wong, G.W., Yang, Y., Yasuda, S., Li, L., Stevens, R.L. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity. Davies, B., Kearns, I.R., Ure, J., Davies, C.H., Lathe, R. J. Neurosci. (2001) [Pubmed]
Assignment of the neuropsin gene (Prss19) to mouse chromosome band 7B4 by in situ hybridization. Yoshida, S., Hirata, A., Inoue, N., Shiosaka, S. Cytogenet. Cell Genet. (2000) [Pubmed]

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