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Gene Review

Fev  -  FEV (ETS oncogene family)

Mus musculus

Synonyms: PC12 ETS domain-containing transcription factor 1, PC12 ETS factor 1, Pet-1, Pet1, Protein FEV, ...
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High impact information on Fev

  • Our results suggest that, during development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples Nkx2-2-mediated early specification with Pet1-mediated terminal differentiation [1].
  • Here we show that in mice lacking Pet-1, the majority of 5-HT neurons fail to differentiate [2].
  • The Pet-1 ETS factor is a precise marker of developing and adult 5-HT neurons and is expressed shortly before 5-HT appears in the hindbrain [2].
  • This approach is based on the ability of a Pet-1 enhancer region to direct reliable 5HT neuron-specific transgene expression in the CNS [3].
  • Remarkably, Pet-1 RNA colocalizes with tryptophan hydroxylase-positive neurons in raphe nuclei but not with their nonserotonergic neuron or non-neuronal neighbors [4].

Biological context of Fev


Anatomical context of Fev

  • The mPet-1 protein is clearly smaller since it lacks the first 103 N-terminal amino acids of rat Pet-1. mPet- 1 is expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood [6].

Associations of Fev with chemical compounds

  • In these regions mPet-1 expression co-localizes precisely with the serotonin transporter (Sert),which it initially precedes [6].

Regulatory relationships of Fev

  • Interestingly, mPet-1 was not found in neurons transiently expressing Sert [6].

Other interactions of Fev


  1. Lmx1b is essential for the development of serotonergic neurons. Ding, Y.Q., Marklund, U., Yuan, W., Yin, J., Wegman, L., Ericson, J., Deneris, E., Johnson, R.L., Chen, Z.F. Nat. Neurosci. (2003) [Pubmed]
  2. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Hendricks, T.J., Fyodorov, D.V., Wegman, L.J., Lelutiu, N.B., Pehek, E.A., Yamamoto, B., Silver, J., Weeber, E.J., Sweatt, J.D., Deneris, E.S. Neuron (2003) [Pubmed]
  3. A genetic approach to access serotonin neurons for in vivo and in vitro studies. Scott, M.M., Wylie, C.J., Lerch, J.K., Murphy, R., Lobur, K., Herlitze, S., Jiang, W., Conlon, R.A., Strowbridge, B.W., Deneris, E.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. Hendricks, T., Francis, N., Fyodorov, D., Deneris, E.S. J. Neurosci. (1999) [Pubmed]
  5. Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. Cheng, L., Chen, C.L., Luo, P., Tan, M., Qiu, M., Johnson, R., Ma, Q. J. Neurosci. (2003) [Pubmed]
  6. mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons. Pfaar, H., von Holst, A., Vogt Weisenhorn, D.M., Brodski, C., Guimera, J., Wurst, W. Dev. Genes Evol. (2002) [Pubmed]
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