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Gene Review

FEV  -  FEV (ETS oncogene family)

Homo sapiens

Synonyms: Fifth Ewing variant protein, HSRNAFEV, PC12 ETS domain-containing transcription factor 1, PC12 ETS factor 1, PET-1, ...
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Disease relevance of FEV

  • Soft tissue Ewing sarcoma--peripheral primitive neuroectodermal tumor with atypical clear cell pattern shows a new type of EWS-FEV fusion transcript [1].
  • The Pet-1 [pheochromocytoma 12 ETS (E26 transformation-specific)] gene plays a critical role in the development of serotonin (5-HT)-modulated behaviors via its control of embryonic 5-HT neuron differentiation [2].
  • Zafirlukast reduced both airway eosinophilia and obstruction in FEV 1 , whereas with a double-blind placebo treatment, the effect of LTE 4 on both parameters persisted for 6 weeks [3].
  • Adjusting for age at measurement, FEV at 0.4 seconds fell by 4.4% for each standard deviation decrease in birth weight (p = 0.047); when adjusted for FVC, FEV at 0.4 seconds was not related to birth weight but fell by 3.2% per standard deviation increase in infant weight gain (p = 0.001) [4].
  • Retrospective analysis of the results of serial ventilatory capacity tests (FEV 1-0), which had extended over an average period of almost 15 years, has been carried out in 215 miners and ex-miners who suffer with coalworkers' pneumoconiosis [5].

Psychiatry related information on FEV


High impact information on FEV

  • 6 of the 10 normal subjects had > 20% reduction in forced expiratory volume in one second (FEV 1) at doses of methacholine < 8 mg/ml, whereas there was < 15% reduction with 75 mg/ml during routine challenge [9].
  • For the group treated with radiation therapy and chemotherapy, there was significantly less improvement after 6 or 12 months in the forced vital capacity (P less than .005) and FEV/1.0 second (P less than .005) than observed for the group treated with chemotherapy alone [10].
  • Following a scheme similar to previously described translocations in Ewing tumors, a t(2;22) chromosome translocation fuses the N-terminal domain of EWS to the ETS DNA binding domain of FEV [11].
  • FEV encodes a 238 amino acid protein which contains an ETS DNA binding domain closely related to that of FLI-1 and ERG [11].
  • The FEV gene is encoded by three exons and is located on chromosome 2 [11].

Chemical compound and disease context of FEV


Biological context of FEV

  • Here, we show, using transgenic methods, that genomic sequences upstream, but not downstream or within the Pet-1-coding region, are sufficient for 5-HT neuron-specific transgene expression [2].
  • A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development [2].
  • In 10 nonsmokers with stable asthma and 10 nonasthmatic nonsmokers, airway mucosal blood flow (Qaw) expressed per milliliter of anatomical dead space and the forced expiratory volume in 1 s (FEV (1)) were determined before and serially after inhalation of FP (88 to 1,760 microg) or placebo [17].
  • Before and up to 30 minutes after each test, specific airway resistance and FEV, were determined [18].
  • No association was observed between daily air pollution concentrations and daily levels of FEV 1 , peak flow, nighttime symptom scores, or asthma exacerbations over the 3-year period [19].

Anatomical context of FEV

  • FEV expression was only detected in adult prostate and small intestine but not in other adult nor in fetal tissues, thus indicating that FEV has a restricted expression pattern [11].
  • Additionally, the degree of branching of AGP in BALF was related to FEV(1), to the provocative dose of histamine causing a 20% decrease in FEV (PD(20)), and to the number of eosinophils [20].
  • RESULTS: In the placebo arm, oral aspirin significantly decreased FEV 1 concomitant with significant increases in sputum eosinophilic cationic protein and urinary leukotriene E(4) levels [21].
  • RESULTS: Leukotriene E 4 inhalation at week 0 doubled the number of eosinophils in the airway mucosa in 21 of 25 patients with mild asthma, increased the numbers of neutrophils and lymphocytes, and decreased FEV 1 (-17%) [3].
  • After familiarization, respiratory muscle strength, inspiratory muscle endurance and the spirometric function (including FVC, FEV 1, FEV1/FVC, tidal volume, breathing rate and duty cycle) were measured [22].

Associations of FEV with chemical compounds

  • The C-terminal end of FEV is rich in alanine residues which may indicate that FEV is a transcription repressor [11].
  • Based on clinical criteria and the ability to raise and maintain for four hours an FEV, by 15% above baseline, ten (50%) of the patients who received isoetharine and 16 (80%) of the patients who received fenoterol therapy were successes [23].
  • Albuterol increased Qaw by 27 +/- 3% in the control subjects (p < 0.01) but had no effect on Qaw in the asthmatic subjects; it increased FEV (1) by 7 +/- 1% and 6 +/- 1% in the two groups, respectively [24].
  • METHODS: Bronchial biopsies were taken and pulmonary function was measured before and 4 to 6 hours after the dose of inhaled LTE 4 causing a > or =15% fall in FEV 1 at baseline both at week 0 and after 6-week randomly assigned treatment with a high dose of zafirlukast, 80 mg twice daily [3].
  • Statistically significant mean increases over the FEV 1 baseline values were recorded after ipratropium treatment in both the initial and the final crossover tests [25].

Other interactions of FEV

  • We have identified a new member of the ETS family, called FEV, which is fused to EWS in a subset of Ewing tumors [11].
  • However, the N-terminal portion of FEV is only 42 amino acids long which suggests that FEV is lacking important transcription regulatory domains contained in FLI-1 and ERG N-terminal parts [11].
  • All patients had a baseline FEV/FVC of less than 65% and their clinical diagnosis were classified as either COPD or bronchial asthma according to the criteria of the ACCP-ATS Joint Committee on Pulmonary Nomenclature [26].
  • Finally, greater SPEos was associated with atopy, higher bronchodilator reversibility, lower FEV 1 /FVC ratio, higher exhaled nitric oxide levels, circulating eosinophils, sputum and serum eosinophil cationic protein, more prednisone courses during the treatment period, and greater asthma severity [27].
  • In contrast, respiratory parameters (%FEV or %FVC) and a nutritional index correlated positively with chloramine levels, whereas negative correlations were observed with taurine and MPO [28].

Analytical, diagnostic and therapeutic context of FEV

  • However, initial pulmonary function tests (PFTs) revealed a significantly lower vital capacity (P = .03) and forced expiratory volume (FEV/1.0 second) (P = .04) in patients with subsequent pulmonary complications [10].
  • Measurement of FEV, and FVC before endoscopy had no predictive value for those patients whose PaO2 fell the most [29].
  • We investigated 60 lung transplant patients (follow-up of 2 to 8 yr) with either histologic evidence of OB within 1 yr after lung transplantation (n = 19) or no pathology, good outcome (GO) for at least 24 mo and well-preserved lung function, i.e., FEV > or = 80% of baseline (n = 41) [30].
  • The effects of (a) regular use for one week and (b) a single dose of a synthetic anticholinergic (ipratropium bromide) on lung mucociliary clearance and as a bronchodilator was ascertained in a controlled, double-blind, cross-over study in 12 patients with reversible airways obstruction (mean increase in FEV after isoprenaline: 17% range 10-50%) [31].
  • Closing volume (single breath nitrogen test), regional ventilation and perfusion (using intravenous xenon-133), and total lung function (TLC, VC, and FEV) were measured before and after intramuscular administration of 250 mug 15-methyl prostaglandin F2alpha (15-me PGF2alpha) in 10 healthy women [32].


  1. Soft tissue Ewing sarcoma--peripheral primitive neuroectodermal tumor with atypical clear cell pattern shows a new type of EWS-FEV fusion transcript. Llombart-Bosch, A., Pellín, A., Carda, C., Noguera, R., Navarro, S., Peydró-Olaya, A. Diagn. Mol. Pathol. (2000) [Pubmed]
  2. A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development. Scott, M.M., Krueger, K.C., Deneris, E.S. J. Neurosci. (2005) [Pubmed]
  3. Leukotriene E(4)-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma. Laitinen, A., Lindqvist, A., Halme, M., Altraja, A., Laitinen, L.A. J. Allergy Clin. Immunol. (2005) [Pubmed]
  4. Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function. Lucas, J.S., Inskip, H.M., Godfrey, K.M., Foreman, C.T., Warner, J.O., Gregson, R.K., Clough, J.B. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  5. Evolution of disability in coalworkers' pneumoconiosis. Lyons, J.P., Campbell, H. Thorax (1976) [Pubmed]
  6. Delaying decline in pulmonary function with physical activity: a 25-year follow-up. Pelkonen, M., Notkola, I.L., Lakka, T., Tukiainen, H.O., Kivinen, P., Nissinen, A. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  7. Effectiveness of behavioral and psychodynamic in-patient treatment of severe obesity--first results from a randomized study. Beutel, M., Thiede, R., Wiltink, J., Sobez, I. Int. J. Obes. Relat. Metab. Disord. (2001) [Pubmed]
  8. Prospective randomized blinded trial of pulmonary function, pain, and cosmetic results after laparoscopic vs. microlaparoscopic cholecystectomy. Schwenk, W., Neudecker, J., Mall, J., Böhm, B., Müller, J.M. Surgical endoscopy. (2000) [Pubmed]
  9. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. Skloot, G., Permutt, S., Togias, A. J. Clin. Invest. (1995) [Pubmed]
  10. Pulmonary toxicity with combined modality therapy for limited stage small-cell lung cancer. Brooks, B.J., Seifter, E.J., Walsh, T.E., Lichter, A.S., Bunn, P.A., Zabell, A., Johnston-Early, A., Edison, M., Makuch, R.W., Cohen, M.H. J. Clin. Oncol. (1986) [Pubmed]
  11. A new member of the ETS family fused to EWS in Ewing tumors. Peter, M., Couturier, J., Pacquement, H., Michon, J., Thomas, G., Magdelenat, H., Delattre, O. Oncogene (1997) [Pubmed]
  12. Further studies of rimiterol and salbutamol administered by intermittent positive-pressure ventilation, and an important observation on the technique of using the Bennett ventilator. Paterson, I.C., Willey, R.F., Shotter, M.V., Crompton, G.K. British journal of clinical pharmacology. (1977) [Pubmed]
  13. One-stage total cystectomy and ileal loop diversion in patients over eighty years' old with bladder carcinoma. Pre- and postoperative functional reserve of various organs. Tachibana, M., Deguchi, N., Jitsukawa, S., Murai, M., Nakazono, M., Tazaki, H. Urology (1983) [Pubmed]
  14. Comparison of post-operative pain, stress response, and quality of life in port access vs. standard sternotomy coronary bypass patients. Grossi, E.A., Zakow, P.K., Ribakove, G., Kallenbach, K., Ursomanno, P., Gradek, C.E., Baumann, F.G., Colvin, S.B., Galloway, A.C. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (1999) [Pubmed]
  15. Respiratory health of plywood workers occupationally exposed to formaldehyde. Malaka, T., Kodama, A.M. Arch. Environ. Health (1990) [Pubmed]
  16. Isolated bronchi of patients with COPD show decreased histamine responsiveness compared to smokers with normal lung function. Taube, C., Einhaus, M., Welker, L., Holz, O., Branscheid, D., Magnussen, H., J??rres, R.A. COPD (2006) [Pubmed]
  17. Transient effect of inhaled fluticasone on airway mucosal blood flow in subjects with and without asthma. Kumar, S.D., Brieva, J.L., Danta, I., Wanner, A. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  18. Methylxanthines inhibit exercise-induced bronchoconstriction at low serum theophylline concentration and in a dose-dependent fashion. Magnussen, H., Reuss, G., Jörres, R. J. Allergy Clin. Immunol. (1988) [Pubmed]
  19. Effects of wintertime ambient air pollutants on asthma exacerbations in urban minority children with moderate to severe disease. Rabinovitch, N., Zhang, L., Murphy, J.R., Vedal, S., Dutton, S.J., Gelfand, E.W. J. Allergy Clin. Immunol. (2004) [Pubmed]
  20. The degree of branching of the glycans of alpha(1)-acid glycoprotein in asthma. A correlation with lung function and inflammatory parameters. Van Den Heuvel, M.M., Poland, D.C., De Graaff, C.S., Hoefsmit, E.C., Postmus, P.E., Beelen, R.H., Van Dijk, W. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  21. Tacrolimus reduces urinary excretion of leukotriene E(4) and inhibits aspirin-induced asthma to threshold dose of aspirin. Kawano, T., Matsuse, H., Kondo, Y., Machida, I., Saeki, S., Tomari, S., Mitsuta, K., Fukushima, C., Obase, Y., Shimoda, T., Kohno, S. J. Allergy Clin. Immunol. (2004) [Pubmed]
  22. Effects of chronic smoking on respiratory muscle function. Chen, H.I. The Chinese journal of physiology. (1988) [Pubmed]
  23. Nebulized isoetharine and fenoterol in acute attacks of asthma. König, P., Hurst, D.J. Arch. Intern. Med. (1983) [Pubmed]
  24. Effect of an inhaled glucocorticosteroid on airway mucosal blood flow in mild asthma. Brieva, J.L., Danta, I., Wanner, A. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  25. Double-blind study of ipratropium bromide, a new anticholinergic bronchodilator. Chervinsky, P. J. Allergy Clin. Immunol. (1977) [Pubmed]
  26. The response pattern of patients with chronic airway obstruction to bronchodilators. Yang, S.C., Wu, M.C. Taiwan Yi Xue Hui Za Zhi (1989) [Pubmed]
  27. Safety and application of induced sputum analysis in childhood asthma. Covar, R.A., Spahn, J.D., Martin, R.J., Silkoff, P.E., Sundstrom, D.A., Murphy, J., Szefler, S.J. J. Allergy Clin. Immunol. (2004) [Pubmed]
  28. Neutrophil-derived long-lived oxidants in cystic fibrosis sputum. Witko-Sarsat, V., Delacourt, C., Rabier, D., Bardet, J., Nguyen, A.T., Descamps-Latscha, B. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  29. Arterial blood gas tensions during upper gastrointestinal endoscopy. Whorwell, P.J., Smith, C.L., Foster, K.J. Gut (1976) [Pubmed]
  30. Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation. Scholma, J., Slebos, D.J., Boezen, H.M., van den Berg, J.W., van der Bij, W., de Boer, W.J., Koëter, G.H., Timens, W., Kauffman, H.F., Postma, D.S. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  31. Effect of ipratropium bromide on mucociliary clearance and pulmonary function in reversible airways obstruction. Pavia, D., Bateman, J.R., Sheahan, N.F., Clarke, S.W. Thorax (1979) [Pubmed]
  32. Pattern of total and regional lung function in subjects with bronchoconstriction induced by 15-me PGF2 alpha. Andersen, L.H., Secher, N.J. Thorax (1976) [Pubmed]
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