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Chemical Compound Review

AC1L9LKM     (2Z)-2-[ (3R,4R,8S,9S,10R,11R,13R,14S,1 6S)...

Synonyms:
 
 
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Disease relevance of fusidic acid

 

High impact information on fusidic acid

 

Chemical compound and disease context of fusidic acid

 

Biological context of fusidic acid

 

Anatomical context of fusidic acid

 

Associations of fusidic acid with other chemical compounds

 

Gene context of fusidic acid

 

Analytical, diagnostic and therapeutic context of fusidic acid

  • To confirm the importance of observed amino acid exchanges in EF-G for the generation of fusidic acid resistance in S. aureus, three mutant fusA alleles encoding EF-G derivatives with the exchanges P406L, H457Y and L461K were constructed by site-directed mutagenesis [16].
  • IF2 prevents the binding of EF-G to the ribosome, as shown by Western blot analysis and fusidic acid-stabilized EF-G.GDP.ribosome complex formation [32].
  • In 10 of these 11 patients, the resistant follow-up isolate(s) belonged to the same PCR ribotype as the susceptible day 1 isolate, confirming frequent emergence of resistance to fusidic acid during treatment [33].
  • The survival time of allografts in mice receiving fusidic acid from the day of the transplantation until the grafts were rejected was 26.1 days compared with 14.5 days in untreated animals [20].
  • In conclusion, culture positivity for C. difficile was common after both fusidic acid and metronidazole therapy and was associated with treatment failure or recurrence of CDAD [33].

References

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  2. Inhibition of HIV replication in vitro by fusidic acid. Faber, V., Dalgleish, A.G., Newell, A., Malkovsky, M. Lancet (1987) [Pubmed]
  3. Fusidic acid, HIV, and host cell toxicity. Richman, D.D., Mitsuya, H., Broder, S., Hostetler, K.Y. Lancet (1988) [Pubmed]
  4. Delayed type hypersensitivity to fusidic acid in patients with chronic dermatitis. Riess, C.E., Bruckner-Tuderman, L. Lancet (1990) [Pubmed]
  5. Granulocytopenia due to fusidic acid. Evans, D.I. Lancet (1988) [Pubmed]
  6. Treatment of chronic endogenous uveitis with fusidic acid. Bendtzen, K., Vesti-Nielsen, N., Petersen, J., Andersen, V., Bendixen, G. Lancet (1991) [Pubmed]
  7. Effect of bile salts and of fusidic acid on HIV-1 infection of cultured cells. Lloyd, G., Atkinson, T., Sutton, P.M. Lancet (1988) [Pubmed]
  8. Post-termination complex disassembly by ribosome recycling factor, a functional tRNA mimic. Hirokawa, G., Kiel, M.C., Muto, A., Selmer, M., Raj, V.S., Liljas, A., Igarashi, K., Kaji, H., Kaji, A. EMBO J. (2002) [Pubmed]
  9. Transcriptional termination at a fully rho-independent site in Escherichia coli is prevented by uninterrupted translation of the nascent RNA. Wright, J.J., Hayward, R.S. EMBO J. (1987) [Pubmed]
  10. Release of ribosome-bound ribosome recycling factor by elongation factor G. Kiel, M.C., Raj, V.S., Kaji, H., Kaji, A. J. Biol. Chem. (2003) [Pubmed]
  11. Outer membranes of gram-negative bacteria are permeable to steroid probes. Plésiat, P., Nikaido, H. Mol. Microbiol. (1992) [Pubmed]
  12. Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus. O'Neill, A.J., Chopra, I. Mol. Microbiol. (2006) [Pubmed]
  13. Fusidic acid alone or in combination with vancomycin for therapy of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Fantin, B., Leclercq, R., Duval, J., Carbon, C. Antimicrob. Agents Chemother. (1993) [Pubmed]
  14. Mathematical modeling of antimicrobial susceptibility data of Staphylococcus haemolyticus for 11 antimicrobial agents, including three experimental glycopeptides and an experimental lipoglycopeptide. Hunter, P.R., George, R.C., Griffiths, J.W. Antimicrob. Agents Chemother. (1990) [Pubmed]
  15. Comparative study of mupirocin and oral co-trimoxazole plus topical fusidic acid in eradication of nasal carriage of methicillin-resistant Staphylococcus aureus. Parras, F., Guerrero, M.C., Bouza, E., Blázquez, M.J., Moreno, S., Menarguez, M.C., Cercenado, E. Antimicrob. Agents Chemother. (1995) [Pubmed]
  16. Molecular analysis of fusidic acid resistance in Staphylococcus aureus. Besier, S., Ludwig, A., Brade, V., Wichelhaus, T.A. Mol. Microbiol. (2003) [Pubmed]
  17. Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp. MacVanin, M., Johanson, U., Ehrenberg, M., Hughes, D. Mol. Microbiol. (2000) [Pubmed]
  18. The effects of pure and micellar solutions of different bile salts on mucosal morphology in rat jejunum in vivo. Keeling, J.W., Lamabadusuriya, S.P., Harries, J.T. J. Pathol. (1976) [Pubmed]
  19. Lack of activity of fusidic acid against human immunodeficiency virus in monocytes. Maehlen, T., Degré, M. Antimicrob. Agents Chemother. (1989) [Pubmed]
  20. Effect of fusidic acid on the immune response in mice. Bellahsène, A., Forsgren, A. Infect. Immun. (1980) [Pubmed]
  21. Interaction of fusidic acid with lipid membranes: Implications to the mechanism of antibiotic activity. Falck, E., Hautala, J.T., Karttunen, M., Kinnunen, P.K., Patra, M., Saaren-Seppälä, H., Vattulainen, I., Wiedmer, S.K., Holopainen, J.M. Biophys. J. (2006) [Pubmed]
  22. The acid phosphatase with optimum pH of 2.5 of Escherichia coli. Physiological and Biochemical study. Dassa, E., Cahu, M., Desjoyaux-Cherel, B., Boquet, P.L. J. Biol. Chem. (1982) [Pubmed]
  23. In vitro activity of ciprofloxacin against gram-positive cocci. Barry, A.L., Jones, R.N. Am. J. Med. (1987) [Pubmed]
  24. Mupirocin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Ward, A., Campoli-Richards, D.M. Drugs (1986) [Pubmed]
  25. Escherichia coli susceptible to glycopeptide antibiotics. Shlaes, D.M., Shlaes, J.H., Davies, J., Williamson, R. Antimicrob. Agents Chemother. (1989) [Pubmed]
  26. Antimicrobial Susceptibility Pattern of Clostridium difficile and Its Relation to PCR Ribotypes in a Swedish University Hospital. Aspevall, O., Lundberg, A., Burman, L.G., Akerlund, T., Svenungsson, B. Antimicrob. Agents Chemother. (2006) [Pubmed]
  27. Sixteen homologs of the mex-type multidrug resistance efflux pump in Bacteroides fragilis. Ueda, O., Wexler, H.M., Hirai, K., Shibata, Y., Yoshimura, F., Fujimura, S. Antimicrob. Agents Chemother. (2005) [Pubmed]
  28. Genetic characterization of the fusidic acid and cadmium resistance determinants of Staphylococcus aureus plasmid pUB101. O'Brien, F.G., Price, C., Grubb, W.B., Gustafson, J.E. J. Antimicrob. Chemother. (2002) [Pubmed]
  29. The Neurospora crassa colonial temperature-sensitive 3 (cot-3) gene encodes protein elongation factor 2. Propheta, O., Vierula, J., Toporowski, P., Gorovits, R., Yarden, O. Mol. Gen. Genet. (2001) [Pubmed]
  30. Effect of fusidic acid on the hepatic cytochrome P450 enzyme system. Reimann, G., Barthel, B., Rockstroh, J.K., Spatz, D., Brockmeyer, N.H. International journal of clinical pharmacology and therapeutics. (1999) [Pubmed]
  31. Effect of fusidic acid on interleukin-1 (IL-1)- and IL-6-induced pancreatic beta-cell functions in rats. Bendtzen, K., Diamant, M., Horn, T., Pedersen, C., Buschard, K. J. Endocrinol. (1992) [Pubmed]
  32. Initiation factor IF2, thiostrepton and micrococcin prevent the binding of elongation factor G to the Escherichia coli ribosome. Cameron, D.M., Thompson, J., March, P.E., Dahlberg, A.E. J. Mol. Biol. (2002) [Pubmed]
  33. Frequent emergence of resistance in Clostridium difficile during treatment of C. difficile-associated diarrhea with fusidic acid. Norén, T., Wullt, M., Akerlund, T., Bäck, E., Odenholt, I., Burman, L.G. Antimicrob. Agents Chemother. (2006) [Pubmed]
 
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