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Chemical Compound Review

AC1L9LKM     (2Z)-2-[ (3R,4R,8S,9S,10R,11R,13R,14S,1 6S)...

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Disease relevance of fusidic acid


High impact information on fusidic acid


Chemical compound and disease context of fusidic acid


Biological context of fusidic acid


Anatomical context of fusidic acid


Associations of fusidic acid with other chemical compounds


Gene context of fusidic acid


Analytical, diagnostic and therapeutic context of fusidic acid

  • To confirm the importance of observed amino acid exchanges in EF-G for the generation of fusidic acid resistance in S. aureus, three mutant fusA alleles encoding EF-G derivatives with the exchanges P406L, H457Y and L461K were constructed by site-directed mutagenesis [16].
  • IF2 prevents the binding of EF-G to the ribosome, as shown by Western blot analysis and fusidic acid-stabilized EF-G.GDP.ribosome complex formation [32].
  • In 10 of these 11 patients, the resistant follow-up isolate(s) belonged to the same PCR ribotype as the susceptible day 1 isolate, confirming frequent emergence of resistance to fusidic acid during treatment [33].
  • The survival time of allografts in mice receiving fusidic acid from the day of the transplantation until the grafts were rejected was 26.1 days compared with 14.5 days in untreated animals [20].
  • In conclusion, culture positivity for C. difficile was common after both fusidic acid and metronidazole therapy and was associated with treatment failure or recurrence of CDAD [33].


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  8. Post-termination complex disassembly by ribosome recycling factor, a functional tRNA mimic. Hirokawa, G., Kiel, M.C., Muto, A., Selmer, M., Raj, V.S., Liljas, A., Igarashi, K., Kaji, H., Kaji, A. EMBO J. (2002) [Pubmed]
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  13. Fusidic acid alone or in combination with vancomycin for therapy of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Fantin, B., Leclercq, R., Duval, J., Carbon, C. Antimicrob. Agents Chemother. (1993) [Pubmed]
  14. Mathematical modeling of antimicrobial susceptibility data of Staphylococcus haemolyticus for 11 antimicrobial agents, including three experimental glycopeptides and an experimental lipoglycopeptide. Hunter, P.R., George, R.C., Griffiths, J.W. Antimicrob. Agents Chemother. (1990) [Pubmed]
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  17. Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp. MacVanin, M., Johanson, U., Ehrenberg, M., Hughes, D. Mol. Microbiol. (2000) [Pubmed]
  18. The effects of pure and micellar solutions of different bile salts on mucosal morphology in rat jejunum in vivo. Keeling, J.W., Lamabadusuriya, S.P., Harries, J.T. J. Pathol. (1976) [Pubmed]
  19. Lack of activity of fusidic acid against human immunodeficiency virus in monocytes. Maehlen, T., Degré, M. Antimicrob. Agents Chemother. (1989) [Pubmed]
  20. Effect of fusidic acid on the immune response in mice. Bellahsène, A., Forsgren, A. Infect. Immun. (1980) [Pubmed]
  21. Interaction of fusidic acid with lipid membranes: Implications to the mechanism of antibiotic activity. Falck, E., Hautala, J.T., Karttunen, M., Kinnunen, P.K., Patra, M., Saaren-Seppälä, H., Vattulainen, I., Wiedmer, S.K., Holopainen, J.M. Biophys. J. (2006) [Pubmed]
  22. The acid phosphatase with optimum pH of 2.5 of Escherichia coli. Physiological and Biochemical study. Dassa, E., Cahu, M., Desjoyaux-Cherel, B., Boquet, P.L. J. Biol. Chem. (1982) [Pubmed]
  23. In vitro activity of ciprofloxacin against gram-positive cocci. Barry, A.L., Jones, R.N. Am. J. Med. (1987) [Pubmed]
  24. Mupirocin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Ward, A., Campoli-Richards, D.M. Drugs (1986) [Pubmed]
  25. Escherichia coli susceptible to glycopeptide antibiotics. Shlaes, D.M., Shlaes, J.H., Davies, J., Williamson, R. Antimicrob. Agents Chemother. (1989) [Pubmed]
  26. Antimicrobial Susceptibility Pattern of Clostridium difficile and Its Relation to PCR Ribotypes in a Swedish University Hospital. Aspevall, O., Lundberg, A., Burman, L.G., Akerlund, T., Svenungsson, B. Antimicrob. Agents Chemother. (2006) [Pubmed]
  27. Sixteen homologs of the mex-type multidrug resistance efflux pump in Bacteroides fragilis. Ueda, O., Wexler, H.M., Hirai, K., Shibata, Y., Yoshimura, F., Fujimura, S. Antimicrob. Agents Chemother. (2005) [Pubmed]
  28. Genetic characterization of the fusidic acid and cadmium resistance determinants of Staphylococcus aureus plasmid pUB101. O'Brien, F.G., Price, C., Grubb, W.B., Gustafson, J.E. J. Antimicrob. Chemother. (2002) [Pubmed]
  29. The Neurospora crassa colonial temperature-sensitive 3 (cot-3) gene encodes protein elongation factor 2. Propheta, O., Vierula, J., Toporowski, P., Gorovits, R., Yarden, O. Mol. Gen. Genet. (2001) [Pubmed]
  30. Effect of fusidic acid on the hepatic cytochrome P450 enzyme system. Reimann, G., Barthel, B., Rockstroh, J.K., Spatz, D., Brockmeyer, N.H. International journal of clinical pharmacology and therapeutics. (1999) [Pubmed]
  31. Effect of fusidic acid on interleukin-1 (IL-1)- and IL-6-induced pancreatic beta-cell functions in rats. Bendtzen, K., Diamant, M., Horn, T., Pedersen, C., Buschard, K. J. Endocrinol. (1992) [Pubmed]
  32. Initiation factor IF2, thiostrepton and micrococcin prevent the binding of elongation factor G to the Escherichia coli ribosome. Cameron, D.M., Thompson, J., March, P.E., Dahlberg, A.E. J. Mol. Biol. (2002) [Pubmed]
  33. Frequent emergence of resistance in Clostridium difficile during treatment of C. difficile-associated diarrhea with fusidic acid. Norén, T., Wullt, M., Akerlund, T., Bäck, E., Odenholt, I., Burman, L.G. Antimicrob. Agents Chemother. (2006) [Pubmed]
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