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Gene Review

GCNT1  -  glucosaminyl (N-acetyl) transferase 1, core 2

Homo sapiens

Synonyms: Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, C2GNT, C2GNT-L, C2GNT1, Core 2 GNT, ...
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Disease relevance of GCNT1


High impact information on GCNT1

  • Previously, we discovered by cloning cDNAs that the core 2 branching enzyme, termed core 2 beta-1,6-N-acetylglucosaminyltransferase-leukocyte type (C2GnT-L), is highly homologous to the I branching beta-1, 6-N-acetylglucosaminyltransferase (IGnT) (Bierhuizen, M. F. A., Mattei, M.-G., and Fukuda, M. (1993) Genes Dev. 7, 468-478) [3].
  • These cells lack endogenous C2GnT activity but express a recombinant human MUC1 cDNA [2].
  • Increased C2GnT expression also led to masking of the SM-3 peptide epitope, which persisted after the removal of sialic acid, further suggesting greater complexity of the core 2-associated O-glycans on MUC1 [2].
  • Following transfection and constitutive expression of full-length exogenous C2GnT transcript, C2GnT enzyme activities were maintained at high levels even after TPA treatment and down-regulation of cell surface sLex antigen expression by TPA was completely abolished [4].
  • However, the up-regulation of C2GnT was more dramatic than that of FucT-VII [5].

Associations of GCNT1 with chemical compounds


Other interactions of GCNT1


  1. An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer. Wang, L., Mitoma, J., Tsuchiya, N., Narita, S., Horikawa, Y., Habuchi, T., Imai, A., Ishimura, H., Ohyama, C., Fukuda, M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Expression of core 2 beta-1,6-N-acetylglucosaminyltransferase in a human pancreatic cancer cell line results in altered expression of MUC1 tumor-associated epitopes. Beum, P.V., Singh, J., Burdick, M., Hollingsworth, M.A., Cheng, P.W. J. Biol. Chem. (1999) [Pubmed]
  3. Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches. Yeh, J.C., Ong, E., Fukuda, M. J. Biol. Chem. (1999) [Pubmed]
  4. Single glycosyltransferase, core 2 beta1-->6-N-acetylglucosaminyltransferase, regulates cell surface sialyl-Lex expression level in human pre-B lymphocytic leukemia cell line KM3 treated with phorbolester. Nakamura, M., Kudo, T., Narimatsu, H., Furukawa, Y., Kikuchi, J., Asakura, S., Yang, W., Iwase, S., Hatake, K., Miura, Y. J. Biol. Chem. (1998) [Pubmed]
  5. Simultaneous core 2 beta1-->6N-acetylglucosaminyltransferase up-regulation and sialyl-Le(X) expression during activation of human tonsillar B lymphocytes. Nakamura, M., Ishida, T., Kikuchi, J., Furukawa, Y., Matsuda, M. FEBS Lett. (1999) [Pubmed]
  6. Core 2 GlcNAc-transferase and polylactosamine expression in O-glycans. Dennis, J.W. Glycobiology (1993) [Pubmed]
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