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Gene Review:

TIMM10B - translocase of inner mitochondrial...

Homo sapiens

Synonyms: FXC1, Fracture callus protein 1, FxC1, Mitochondrial import inner membrane translocase subunit Tim10 B, Mitochondrial import inner membrane translocase subunit Tim9 B, ...

Hadjiargyrou, M. et al., Diamond, T.H. et al., Wilkinson, F. et al., Meyer, M.H. et al., Gerstenfeld, L.C. et al., et al.

Diamond, Clark, Kumar,

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Disease relevance of FXC1

Fracture callus in osteopetrosis [1].

High impact information on FXC1

In fracture callus samples from three patients, VCAF was detected in osteoblasts and microvessels [2].
CONCLUSION: Our data demonstrates a mixed fracture callus with overlapping of the various stages of fracture healing [3].
Genes with greater up-regulation in the fracture callus of older rats with delayed healing [4].
Three-dimensional Reconstruction of Fracture Callus Morphogenesis [5].
Utilizing 5' RACE PCR, a 598-bp full-length cDNA was obtained for FxC1 that contains an open reading frame (ORF) of 243 bp, encoding for an 80 amino acid protein [6].

Biological context of FXC1

During the differentiation of MC3T3 cells along the osteoblast lineage, FxC1 expression increases 3- to 4-fold during the production and deposition of matrix proteins, suggesting a possible role for this protein in cell differentiation [6].

References

Fracture callus in osteopetrosis. de Palma, L., Tulli, A., Maccauro, G., Sabetta, S.P., del Torto, M. Clin. Orthop. Relat. Res. (1994) [Pubmed]
Contribution of VCAF-positive cells to neovascularization and calcification in atherosclerotic plaque development. Wilkinson, F., Liu, Y., Rucka, A., Jeziorska, M., Hoyland, J., Heagerty, A., Canfield, A., Alexander, M. J. Pathol. (2007) [Pubmed]
Histomorphometric analysis of fracture healing cascade in acute osteoporotic vertebral body fractures. Diamond, T.H., Clark, W.A., Kumar, S.V. Bone (2007) [Pubmed]
Genes with greater up-regulation in the fracture callus of older rats with delayed healing. Meyer, M.H., Meyer, R.A. J. Orthop. Res. (2007) [Pubmed]
Three-dimensional Reconstruction of Fracture Callus Morphogenesis. Gerstenfeld, L.C., Alkhiary, Y.M., Krall, E.A., Nicholls, F.H., Stapleton, S.N., Fitch, J.L., Bauer, M., Kayal, R., Graves, D.T., Jepsen, K.J., Einhorn, T.A. J. Histochem. Cytochem. (2006) [Pubmed]
Cloning of a novel cDNA expressed during the early stages of fracture healing. Hadjiargyrou, M., Halsey, M.F., Ahrens, W., Rightmire, E.P., McLeod, K.J., Rubin, C.T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]

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TIMM10B	Bos taurus
FXC1	Canis lupus familiaris
timm10b	Danio rerio
FXC1	Macaca mulatta
Timm10b	Mus musculus
TIMM10B	Pan troglodytes
Timm10b	Rattus norvegicus

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