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Gene Review:

PCOLCE2 - procollagen C-endopeptidase enhancer 2

Homo sapiens

Synonyms: PCPE-2, PCPE2, Procollagen C-endopeptidase enhancer 2, Procollagen C-proteinase enhancer 2, Procollagen COOH-terminal proteinase enhancer 2, ...

Steiglitz, B.M. et al., Xu, H. et al., Steiglitz, B.M. et al.

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High impact information on PCOLCE2

PCPE2 is also shown to have markedly stronger affinity for heparin than PCPE1, which may account for higher affinities for cell layers [1].
PCPE2 is shown to be a glycoprotein that differs markedly in the nature of its glycosylation from that of PCPE1 [1].
Based upon its homology with collagen-binding proteins, its expression in the trabecular meshwork, and its chromosome location, PCOLCE2 is a candidate gene for GLC1C [2].
PCOLCE2, a 52-kDa protein, is expressed in the trabecular meshwork [2].
Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23 [3].

References

PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. Steiglitz, B.M., Keene, D.R., Greenspan, D.S. J. Biol. Chem. (2002) [Pubmed]
Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24. Xu, H., Acott, T.S., Wirtz, M.K. Genomics (2000) [Pubmed]
Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23. Steiglitz, B.M., Greenspan, D.S. Cytogenet. Cell Genet. (2001) [Pubmed]

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