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MeSH Review

Trabecular Meshwork

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Disease relevance of Trabecular Meshwork


High impact information on Trabecular Meshwork

  • A gene encoding a trabecular meshwork protein (TIGR) mapped to the narrowest disease interval by STS content and radiation hybrid mapping [6].
  • In the human eye, optimedin is expressed in the retina and the trabecular meshwork [7].
  • CYP1B1 gene has previously been mapped within the GLC3A candidate region and its expression in the trabecular meshwork cells has been demonstrated in this study [8].
  • Human trabecular meshwork cells isolated from the eye were plated on type III 7-10 repeats of fibronectin (alpha5beta1 ligand) in the absence or presence of the heparin (Hep) II domain of fibronectin [9].
  • This novel pathway demonstrates a cooperative, rather than antagonistic, role between alpha5beta1 and alpha4beta1 integrins and suggests that interactions between the Hep II domain and alpha4beta1 integrin could modulate the strength of cytoskeleton-mediated processes in the trabecular meshwork of the human eye [9].

Chemical compound and disease context of Trabecular Meshwork


Biological context of Trabecular Meshwork


Anatomical context of Trabecular Meshwork


Associations of Trabecular Meshwork with chemical compounds


Gene context of Trabecular Meshwork


Analytical, diagnostic and therapeutic context of Trabecular Meshwork


  1. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Wang, N., Chintala, S.K., Fini, M.E., Schuman, J.S. Nat. Med. (2001) [Pubmed]
  2. Potentiation of glucocorticoid activity by 5 beta-dihydrocortisol: its role in glaucoma. Weinstein, B.I., Gordon, G.G., Southren, A.L. Science (1983) [Pubmed]
  3. Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells. Clark, A.F., Wilson, K., McCartney, M.D., Miggans, S.T., Kunkle, M., Howe, W. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  4. Introduction of DNA into the rat and primate trabecular meshwork by fusogenic liposomes. Hangai, M., Tanihara, H., Honda, Y., Kaneda, Y. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  5. Effect of high glucose on fibronectin expression and cell proliferation in trabecular meshwork cells. Sato, T., Roy, S. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  6. Identification of a gene that causes primary open angle glaucoma. Stone, E.M., Fingert, J.H., Alward, W.L., Nguyen, T.D., Polansky, J.R., Sunden, S.L., Nishimura, D., Clark, A.F., Nystuen, A., Nichols, B.E., Mackey, D.A., Ritch, R., Kalenak, J.W., Craven, E.R., Sheffield, V.C. Science (1997) [Pubmed]
  7. Optimedin: a novel olfactomedin-related protein that interacts with myocilin. Torrado, M., Trivedi, R., Zinovieva, R., Karavanova, I., Tomarev, S.I. Hum. Mol. Genet. (2002) [Pubmed]
  8. Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Stoilov, I., Akarsu, A.N., Sarfarazi, M. Hum. Mol. Genet. (1997) [Pubmed]
  9. Heparin II domain of fibronectin uses alpha4beta1 integrin to control focal adhesion and stress fiber formation, independent of syndecan-4. Peterson, J.A., Sheibani, N., David, G., Garcia-Pardo, A., Peters, D.M. J. Biol. Chem. (2005) [Pubmed]
  10. Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes. Clark, A.F., Wilson, K., de Kater, A.W., Allingham, R.R., McCartney, M.D. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  11. Defects in cortisol-metabolizing enzymes in primary open-angle glaucoma. Weinstein, B.I., Munnangi, P., Gordon, G.G., Southren, A.L. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  12. Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor. Fautsch, M.P., Bahler, C.K., Vrabel, A.M., Howell, K.G., Loewen, N., Teo, W.L., Poeschla, E.M., Johnson, D.H. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  13. Melanin in the trabecular meshwork is associated with age, POAG but not Latanoprost treatment. A masked morphometric study. Cracknell, K.P., Grierson, I., Hogg, P., Majekodunmi, A.A., Watson, P., Marmion, V. Exp. Eye Res. (2006) [Pubmed]
  14. Ethacrynic acid: outflow effects and toxicity in human trabecular meshwork in perfusion organ culture. Johnson, D.H., Tschumper, R.C. Curr. Eye Res. (1993) [Pubmed]
  15. Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma. Liu, Y., Vollrath, D. Hum. Mol. Genet. (2004) [Pubmed]
  16. Extracellular trafficking of myocilin in human trabecular meshwork cells. Hardy, K.M., Hoffman, E.A., Gonzalez, P., McKay, B.S., Stamer, W.D. J. Biol. Chem. (2005) [Pubmed]
  17. Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans. Elliott, W.J., Karnezis, T.A., Silverman, R.A., Geanon, J., Tripathi, R.C., Murphy, M.B. Clin. Pharmacol. Ther. (1991) [Pubmed]
  18. Hepatocyte growth factor/scatter factor in the eye. Grierson, I., Heathcote, L., Hiscott, P., Hogg, P., Briggs, M., Hagan, S. Progress in retinal and eye research. (2000) [Pubmed]
  19. Effects of prostaglandin analogues on human ciliary muscle and trabecular meshwork cells. Zhao, X., Pearson, K.E., Stephan, D.A., Russell, P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  20. Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor. Jacobson, N., Andrews, M., Shepard, A.R., Nishimura, D., Searby, C., Fingert, J.H., Hageman, G., Mullins, R., Davidson, B.L., Kwon, Y.H., Alward, W.L., Stone, E.M., Clark, A.F., Sheffield, V.C. Hum. Mol. Genet. (2001) [Pubmed]
  21. Adenovirus-mediated gene therapy for corneal clouding in mice with mucopolysaccharidosis type VII. Kamata, Y., Okuyama, T., Kosuga, M., O'hira, A., Kanaji, A., Sasaki, K., Yamada, M., Azuma, N. Mol. Ther. (2001) [Pubmed]
  22. Ascorbic acid modulates the production of fibronectin and laminin by cells from an eye tissue-trabecular meshwork. Yue, B.Y., Higginbotham, E.J., Chang, I.L. Exp. Cell Res. (1990) [Pubmed]
  23. Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells. Nguyen, T.D., Chen, P., Huang, W.D., Chen, H., Johnson, D., Polansky, J.R. J. Biol. Chem. (1998) [Pubmed]
  24. The regulation of trabecular meshwork and ciliary muscle contractility. Wiederholt, M., Thieme, H., Stumpff, F. Progress in retinal and eye research. (2000) [Pubmed]
  25. Anterior segment physiology after bumetanide inhibition of Na-K-Cl cotransport. Gabelt, B.T., Wiederholt, M., Clark, A.F., Kaufman, P.L. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  26. Molecular cloning of the bovine MYOC and induction of its expression in trabecular meshwork cells. Taniguchi, F., Suzuki, Y., Kurihara, H., Kurihara, Y., Kasai, H., Shirato, S., Araie, M. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  27. Induction of tissue transglutaminase in the trabecular meshwork by TGF-beta1 and TGF-beta2. Welge-Lüssen, U., May, C.A., Lütjen-Drecoll, E. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  28. Involvement of the Erk-MAP kinase pathway in TNFalpha regulation of trabecular matrix metalloproteinases and TIMPs. Alexander, J.P., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  29. Insulin-like growth factor binding protein-5 expression by human trabecular meshwork. Wirtz, M.K., Xu, H., Rust, K., Alexander, J.P., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  30. The effect of dexamethasone on glycosaminoglycans of human trabecular meshwork in perfusion organ culture. Johnson, D.H., Bradley, J.M., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  31. Recombinant TIGR/MYOC increases outflow resistance in the human anterior segment. Fautsch, M.P., Bahler, C.K., Jewison, D.J., Johnson, D.H. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  32. Noladin Ether Acts on Trabecular Meshwork Cannabinoid (CB1) Receptors to Enhance Aqueous Humor Outflow Facility. Njie, Y.F., Kumar, A., Qiao, Z., Zhong, L., Song, Z.H. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  33. IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork. Hosseini, M., Rose, A.Y., Song, K., Bohan, C., Alexander, J.P., Kelley, M.J., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
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