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Gene Review:

SNORD42A - small nucleolar RNA, C/D box 42A

Homo sapiens

Synonyms: RNU42A, U42, U42A

Guinet, E. et al., Klostermeier, D. et al., Butcher, S.E. et al., Young, K.J. et al., Fujiwara, N. et al.

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Disease relevance of SNORD42A

While performing a differential display analysis of the promonocytic cell line U937 and clone U42 HIV infected counterpart, we found, out of about 15 highly dysregulated genes, expected according to our previous proteomic analysis, two dysregulated cellular transcripts that are shown in the present study to colocalize on band 22q11 [1].

High impact information on SNORD42A

The results demonstrate that each pyrimidine (U41, U42 and C25) plays an important role in hairpin ribozyme catalysis [2].
To elucidate the determinants for tertiary structure stability in the hairpin ribozyme, we evaluated the energetic contributions of hydrogen bonds surrounding U42 and G+1 by time-resolved fluorescence resonance energy transfer using modified ribozymes that lack one or more of the individual interactions [3].
A second cross-link forms between nucleotides A20 and U42 as a result of ribozyme dimerization at concentrations greater than 0.5 microM [4].
Competitive PCR was performed using primer sets in the U42 gene of each viral genome [5].

References

Do retroviruses preferentially integrate within highly plastic regions of the human genome? Guinet, E., Mimaud, V., Rossignol, P., Hameau, L., Benboudjema, L., Jasmin, C., Tovey, M.G., Bélec, L., Lang, M.C. Med. Hypotheses (2003) [Pubmed]
The role of essential pyrimidines in the hairpin ribozyme-catalysed reaction. Young, K.J., Vyle, J.S., Pickering, T.J., Cohen, M.A., Holmes, S.C., Merkel, O., Grasby, J.A. J. Mol. Biol. (1999) [Pubmed]
Energetics of hydrogen bond networks in RNA: hydrogen bonds surrounding G+1 and U42 are the major determinants for the tertiary structure stability of the hairpin ribozyme. Klostermeier, D., Millar, D.P. Biochemistry (2002) [Pubmed]
A photo-cross-linkable tertiary structure motif found in functionally distinct RNA molecules is essential for catalytic function of the hairpin ribozyme. Butcher, S.E., Burke, J.M. Biochemistry (1994) [Pubmed]
Monitoring of human herpesvirus-6 and -7 genomes in saliva samples of healthy adults by competitive quantitative PCR. Fujiwara, N., Namba, H., Ohuchi, R., Isomura, H., Uno, F., Yoshida, M., Nii, S., Yamada, M. J. Med. Virol. (2000) [Pubmed]

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