Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Ctsj - cathepsin J

Mus musculus

Synonyms: CATP, Cat P, CatRLP, Cathepsin J, Cathepsin L-related protein, ...

Nakajima, A. et al., Mason, R.W. et al., Deussing, J. et al., Stoka, V. et al.

Mason, Bergman, Lu, Frenck Holbrook, Sol-Church, Deussing, Kouadio, Rehman, Werber, Schwinde, Peters,

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High impact information on Ctsj

In contrast, a cathepsin L-related protease from the protozoan parasite Trypanosoma cruzi, cruzipain, showed a measurable caspase activation rate [1].
Cathepsin-6 showed the highest homology with cathepsin J (same as P) and L [2].
Genes encoding novel murine cysteine peptidases of the papain family C1A and related genes were cloned and mapped to mouse chromosome 13, colocalizing with the previously assigned cathepsin J gene [3].
In the present study, it was shown that cathepsin P can be expressed in Pichia pastoris as an inactive zymogen that can be activated with proteinase K, chymotrypsin or pancreatic elastase at neutral pH [4].

Anatomical context of Ctsj

The expression of cathepsin-6 and cathepsin J/P was restricted in labyrinthine trophoblasts of the placenta [2].

Associations of Ctsj with chemical compounds

Cathepsin-6, a novel cysteine proteinase showing homology with and co-localized expression with cathepsin J/P in the labyrinthine layer of mouse placenta [2].

References

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. Stoka, V., Turk, B., Schendel, S.L., Kim, T.H., Cirman, T., Snipas, S.J., Ellerby, L.M., Bredesen, D., Freeze, H., Abrahamson, M., Bromme, D., Krajewski, S., Reed, J.C., Yin, X.M., Turk, V., Salvesen, G.S. J. Biol. Chem. (2001) [Pubmed]
Cathepsin-6, a novel cysteine proteinase showing homology with and co-localized expression with cathepsin J/P in the labyrinthine layer of mouse placenta. Nakajima, A., Kataoka, K., Takata, Y., Huh, N.H. Biochem. J. (2000) [Pubmed]
Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Deussing, J., Kouadio, M., Rehman, S., Werber, I., Schwinde, A., Peters, C. Genomics (2002) [Pubmed]
Expression and characterization of cathepsin P. Mason, R.W., Bergman, C.A., Lu, G., Frenck Holbrook, J., Sol-Church, K. Biochem. J. (2004) [Pubmed]

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