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Gene Review

Setx  -  senataxin

Mus musculus

Synonyms: A130090N03, A930037J23Rik, AOA2, AW060766, Als4, ...
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Disease relevance of Setx

  • These fragments completely blocked actin tail formation and motility of Listeria, both in mouse brain extract and in Ptk2 cells overexpressing Scar1 constructs [1].
  • The Arp2/3 complex also interacts with members of the Wiskott-Aldrich syndrome protein (WASP) [8] family - Scar1 [9] [10] and WASP itself [11] [1].

High impact information on Setx

  • Here, we study the involvement of Scar1, Scar2, N-WASP, and Arp2/3 complex in dorsal ruffle formation in mouse embryonic fibroblasts (MEFs) [2].

Biological context of Setx

  • Moreover, overexpression of N-terminal fragments of Scar2 (but not N-WASP or Scar1 or Scar3) interfere with NIH 3T3 Golgi polarization but not with cell migration [3].


  1. The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes. May, R.C., Hall, M.E., Higgs, H.N., Pollard, T.D., Chakraborty, T., Wehland, J., Machesky, L.M., Sechi, A.S. Curr. Biol. (1999) [Pubmed]
  2. N-wasp involvement in dorsal ruffle formation in mouse embryonic fibroblasts. Legg, J.A., Bompard, G., Dawson, J., Morris, H.L., Andrew, N., Cooper, L., Johnston, S.A., Tramountanis, G., Machesky, L.M. Mol. Biol. Cell (2007) [Pubmed]
  3. Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models. Magdalena, J., Millard, T.H., Etienne-Manneville, S., Launay, S., Warwick, H.K., Machesky, L.M. Mol. Biol. Cell (2003) [Pubmed]
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