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Gene Review

Wasf3  -  WAS protein family, member 3

Mus musculus

Synonyms: Protein WAVE-3, Scar3, WASP family protein member 3, Wave3, Wiskott-Aldrich syndrome protein family member 3
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Disease relevance of Wasf3

  • We have identified the WAVE3 gene from Chromosome (Chr) 13q12, as being involved in one of the breakpoints of a t(1:13)(q21:q12) reciprocal translocation, in a patient with ganglioneuroblastoma (Sossey-Alaoui et al. 2002; Oncogene 21: 5967-5974) [1].

High impact information on Wasf3

  • WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma [2].
  • From analysis of its expression pattern and function, WAVE3 is a candidate tumor suppressor gene, at least in some forms of neuroblastoma [2].
  • WAVE3, therefore, is important for cell differentiation and motility and its expression is lost in a number of low grade and stage 4S tumors [2].
  • The WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization [2].
  • Constitutive Rac activation translocates WAVE3 (via the N-terminus), to the leading edge of lamellipodia [3].

Biological context of Wasf3

  • Positional cloning of the translocation breakpoint on chromosome 13 resulted in the mapping of the breakpoint between coding exon 2 and exon 3 of WAVE3, a member of WASP gene family [2].

Anatomical context of Wasf3


Other interactions of Wasf3


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