Disease relevance of CYFIP2

• CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion [1].

High impact information on CYFIP2

• These studies suggest that overabundance of CYFIP2 protein facilitates increased adhesion properties of T cells from MS patients [1].
• Finally, inhibition of Rac-1 or reduction of CYFIP2 protein decreased fibronectin-mediated adhesion in CD4(+) cells from MS patients to levels similar to controls [1].
• First, adenoviral-mediated overexpression of CYFIP2 in Jurkat cells increased fibronectin-mediated adhesion [1].
• Inducible expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation [2].
• Here we show that the CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter [2].

Associations of CYFIP2 with chemical compounds

• CYFIP2, a direct p53 target, is leptomycin-B sensitive [2].

Other interactions of CYFIP2

• Western analysis confirmed that CYFIP2 protein was increased approximately fourfold in CD4(+) cells from MS compared to inflammatory bowel disorder (IBD) patients or healthy controls [1].

Analytical, diagnostic and therapeutic context of CYFIP2

• DNA microarray profiling of CD4(+) and CD8(+) cells from non-treated relapsing and remitting multiple sclerosis (MS) patients determined that the cytoplasmic binding partner of fragile X protein (CYFIP2, also called PIR121) was increased significantly compared to healthy controls [1].

References