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Gene Review

CYFIP2  -  cytoplasmic FMR1 interacting protein 2

Homo sapiens

Synonyms: Cytoplasmic FMR1-interacting protein 2, KIAA1168, PIR121, p53-inducible protein 121
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Disease relevance of CYFIP2


High impact information on CYFIP2

  • These studies suggest that overabundance of CYFIP2 protein facilitates increased adhesion properties of T cells from MS patients [1].
  • Finally, inhibition of Rac-1 or reduction of CYFIP2 protein decreased fibronectin-mediated adhesion in CD4(+) cells from MS patients to levels similar to controls [1].
  • First, adenoviral-mediated overexpression of CYFIP2 in Jurkat cells increased fibronectin-mediated adhesion [1].
  • Inducible expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation [2].
  • Here we show that the CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter [2].

Associations of CYFIP2 with chemical compounds


Other interactions of CYFIP2

  • Western analysis confirmed that CYFIP2 protein was increased approximately fourfold in CD4(+) cells from MS compared to inflammatory bowel disorder (IBD) patients or healthy controls [1].

Analytical, diagnostic and therapeutic context of CYFIP2

  • DNA microarray profiling of CD4(+) and CD8(+) cells from non-treated relapsing and remitting multiple sclerosis (MS) patients determined that the cytoplasmic binding partner of fragile X protein (CYFIP2, also called PIR121) was increased significantly compared to healthy controls [1].


  1. CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion. Mayne, M., Moffatt, T., Kong, H., McLaren, P.J., Fowke, K.R., Becker, K.G., Namaka, M., Schenck, A., Bardoni, B., Bernstein, C.N., Melanson, M. Eur. J. Immunol. (2004) [Pubmed]
  2. CYFIP2, a direct p53 target, is leptomycin-B sensitive. Jackson, R.S., Cho, Y.J., Stein, S., Liang, P. Cell Cycle (2007) [Pubmed]
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