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Gene Review

Sra-1  -  specifically Rac1-associated protein 1

Drosophila melanogaster

Synonyms: CG4931, CYFIP, CYFIP1/2, Cyfip, Cytoplasmic FMR1-interacting protein, ...
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High impact information on Sra-1

  • WAVE function is regulated through a protein complex containing Sra1, Kette and Abi [1].
  • Finally, CYFIP acts as a dRac1 effector that antagonizes FMR1 function, providing a bridge between signal-dependent cytoskeleton remodeling and translation [2].
  • Outgrowing photoreceptor neurons express high levels of Sra-1 also in growth cones [3].
  • During late embryonic and larval development, the Sra-1 protein is found in the neuropile [3].
  • Hyperactivation of calcineurin signaling in the germline cells resulted in a meiotic-arrest phenotype, which can also be suppressed by overexpression of Sra [4].

Biological context of Sra-1

  • Similar mutant phenotypes were induced after expression of membrane-bound Sra-1 that lacks the Kette-binding domain, suggesting that sra-1 function is mediated through kette [3].
  • All these results support the hypothesis that Sra regulates female meiosis by controlling calcineurin activity in the germline [4].
  • Sra is physically associated with the catalytic subunit of calcineurin, and its overexpression suppresses the phenotypes caused by constitutively activated calcineurin, such as rough eye or loss of wing veins [4].

Anatomical context of Sra-1

  • Here we show that the Drosophila proteins SCAR, CYFIP and Kette, orthologs of WAVE/SCAR complex components, all show strong accumulation in axons of the central nervous system and indeed form a complex in vivo [5].

Other interactions of Sra-1

  • We also show that RNAi of three proteins (kette, Abi, and Sra-1) known to copurify with and inhibit SCAR in vitro leads to SCAR degradation, revealing a novel function of this protein complex in SCAR stability [6].


  1. Abi activates WASP to promote sensory organ development. Bogdan, S., Stephan, R., Löbke, C., Mertens, A., Klämbt, C. Nat. Cell Biol. (2005) [Pubmed]
  2. CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J.L., Giangrande, A. Neuron (2003) [Pubmed]
  3. Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila. Bogdan, S., Grewe, O., Strunk, M., Mertens, A., Klämbt, C. Development (2004) [Pubmed]
  4. The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. Takeo, S., Tsuda, M., Akahori, S., Matsuo, T., Aigaki, T. Curr. Biol. (2006) [Pubmed]
  5. WAVE/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity. Schenck, A., Qurashi, A., Carrera, P., Bardoni, B., Diebold, C., Schejter, E., Mandel, J.L., Giangrande, A. Dev. Biol. (2004) [Pubmed]
  6. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. Rogers, S.L., Wiedemann, U., Stuurman, N., Vale, R.D. J. Cell Biol. (2003) [Pubmed]
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