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Gene Review:

US1 - required for expression of a subset of...

Human herpesvirus 1

Umene, K. et al., Remeijer, L. et al., Orlando, J.S. et al.

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Disease relevance of US1

The products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells [1].
METHODS: From 30 patients with RHK, sequential corneal HSV-1 isolates were genotyped by PCR amplification of the hypervariable regions located within the HSV-1 genes US1, US10/11, and US12 [2].

High impact information on US1

Variations in length of the major DNA fragment, containing reiteration I (within the a sequence) and/or reiteration IV (within introns of genes US1 and US12), were detected between isolates of each multiple-recurrence set, but not of the primary-recurrence set [3].

References

The products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells. Orlando, J.S., Astor, T.L., Rundle, S.A., Schaffer, P.A. J. Virol. (2006) [Pubmed]
Corneal herpes simplex virus type 1 superinfection in patients with recrudescent herpetic keratitis. Remeijer, L., Maertzdorf, J., Buitenwerf, J., Osterhaus, A.D., Verjans, G.M. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
Divergence of reiterated sequences in a series of genital isolates of herpes simplex virus type 1 from individual patients. Umene, K., Kawana, T. J. Gen. Virol. (2003) [Pubmed]

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