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Gene Review:

IL36B - interleukin 36, beta

Homo sapiens

Synonyms: FIL1, FIL1 eta, FIL1-(ETA), FIL1H, FILI-(ETA), ...

Magne, D. et al.

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Disease relevance of IL1F8

Serum levels of IL-1F8 were similar in healthy donors, and patients with rheumatoid arthritis, osteoarthritis and septic shock, and did not correlate with inflammatory status [1].

High impact information on IL1F8

The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes [1].
IL-1F8 levels in synovial fluids were similar to or lower than those in matched serum samples, suggesting that the joint itself is not a major source of IL-1F8 [1].

Anatomical context of IL1F8

Human synovial fibroblasts (hSFs) and human articular chondrocytes (hACs) expressed the IL-1F8 receptor (IL-1Rrp2) and produced pro-inflammatory mediators in response to recombinant IL-1F8 [1].

References

The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Magne, D., Palmer, G., Barton, J.L., Mézin, F., Talabot-Ayer, D., Bas, S., Duffy, T., Noger, M., Guerne, P.A., Nicklin, M.J., Gabay, C. Arthritis Res. Ther. (2006) [Pubmed]

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IL36B	Bos taurus
LOC483068	Canis lupus familiaris
IL1F8	Macaca mulatta
Il1f8	Mus musculus
Il36b	Rattus norvegicus

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