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Gene Review:

IL37 - interleukin 37

Homo sapiens

Synonyms: FIL1, FIL1 zeta, FIL1(ZETA), FIL1Z, IL-1 zeta, ...

Gao, W. et al., Chen, H.Y. et al., Ishihara, O. et al., Benedict, C.A. et al., Watanabe, E. et al., et al.

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Disease relevance of IL1F7

In this issue of Immunity, a report by Johnston and colleagues reveals a poxvirus strategy that inhibits the inflammasome, arresting secretion of interleukin-1-related cytokines, thus silencing key alarms that mobilize host defenses [1].
Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms [2].

High impact information on IL1F7

Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity [3].
Fil1, a G-protein alpha-subunit that acts upstream of cAMP and is essential for dimorphic switching in haploid cells of Ustilago hordei [4].
RESULTS: The prevalence of each genotype of the interleukin-1 related genes in the study population was: (1) 14% C/C, 71.5% C/T, and 14.5% T/T in IL-1beta promoter; (2) 95.3% E1/E1 and 4.7% E1/E2 in IL-1beta exon 5; (3) 92.4% I/I, 6.4% I/II, and 1.2% II/II in IL-1Ra intron 2 [5].
Frigen II improves the reliability of measurement of interleukin-1 related substances in amniotic fluid [6].
Genetic and physical analyses place the Fil1 locus and the deletion near the terminus of one arm of the 940-kb chromosome [7].

Anatomical context of IL1F7

BACKGROUND: To investigate the role of interleukin-1 related substances in amniotic fluid in normal term labor without intrauterine infection [6].

Analytical, diagnostic and therapeutic context of IL1F7

These results suggest that IL-1H4 could play an important role in the link between innate and adaptive immunity and may be useful for tumor immunotherapy [3].
In situ hybridization data demonstrate that tap1 is expressed in the tapetum of the anthers and fil1 in the filament of the stamen and at the bases of the petals [8].

References

Poxviruses aren't stuPYD. Benedict, C.A., Ware, C.F. Immunity (2005) [Pubmed]
Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms. Watanabe, E., Hirasawa, H., Oda, S., Matsuda, K., Hatano, M., Tokuhisa, T. Crit. Care Med. (2005) [Pubmed]
Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. Gao, W., Kumar, S., Lotze, M.T., Hanning, C., Robbins, P.D., Gambotto, A. J. Immunol. (2003) [Pubmed]
Fil1, a G-protein alpha-subunit that acts upstream of cAMP and is essential for dimorphic switching in haploid cells of Ustilago hordei. Lichter, A., Mills, D. Mol. Gen. Genet. (1997) [Pubmed]
Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphism in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis. Chen, H.Y., Chen, W.C., Wu, M.C., Tsai, F.J., Lin, C.C. Maturitas. (2003) [Pubmed]
Frigen II improves the reliability of measurement of interleukin-1 related substances in amniotic fluid. Ishihara, O., Saitoh, M., Kinoshita, K., Takanashi, H., Arai, Y., Kitagawa, H. Acta obstetricia et gynecologica Scandinavica. (1999) [Pubmed]
Characterization of genome plasticity in Ustilago hordei. McCluskey, K., Agnan, J., Mills, D. Curr. Genet. (1994) [Pubmed]
Molecular characterization of two stamen-specific genes, tap1 and fil1, that are expressed in the wild type, but not in the deficiens mutant of Antirrhinum majus. Nacken, W.K., Huijser, P., Beltran, J.P., Saedler, H., Sommer, H. Mol. Gen. Genet. (1991) [Pubmed]

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IL37	Bos taurus
IL37	Canis lupus familiaris
LOC700579	Macaca mulatta

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